一种镶嵌抗性（OXA-48）和毒力（气杆菌素）质粒在欧洲的跨境传播：欧洲抗菌药物耐药基因监测网络调查，欧洲，2019年2月至2024年10月
Cross-border spread of a mosaic resistance (OXA-48) and virulence (aerobactin) plasmid in : a European Antimicrobial Resistance Genes Surveillance Network investigation, Europe, February 2019 to October 2024.
作者信息
Linkevicius Marius, Alm Erik, Roer Louise, Svartström Olov, Dada-Olorunwa Maria, Räisänen Kati, Reichert Felix, Möller Sophie, Clarke Christina, Cormican Martin, Niedre-Otomere Baiba, Vangravs Reinis, Greičius Paulius, Burduniuc Olga, Anton Maria, Hendrickx Antoni P A, Witteveen Sandra, Müller Vilhelm, Palm Daniel, Plachouras Diamantis, Monnet Dominique L, Hasman Henrik, Kohlenberg Anke
机构信息
European Centre for Disease Prevention and Control, Stockholm, Sweden.
European Society for Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mobile Elements and Plasmids (ESGMAP), Basel, Switzerland.
出版信息
Euro Surveill. 2025 Jul;30(27). doi: 10.2807/1560-7917.ES.2025.30.27.2500439.
An investigation of the European Antimicrobial Resistance Genes Surveillance Network (EURGen-Net) detected the same mosaic IncHI1B(pNDM-MAR) resistance (OXA-48) and virulence (aerobactin) plasmid in 492 isolates from eight European Union countries during 2019-2024. Involvement of various sequence types (STs), multiple introductions, followed by large clonal outbreaks of three STs (ST147, ST392, ST45) carrying the plasmid in two countries indicate a high risk for further spread of this plasmid and a potential for difficult-to-treat infections to rise.
欧洲抗菌药物耐药基因监测网络（EURGen-Net）的一项调查发现，在2019年至2024年期间，来自八个欧盟国家的492株分离菌中存在相同的嵌合IncHI1B(pNDM-MAR)耐药（OXA-48）和毒力（气杆菌素）质粒。多种序列类型（STs）的参与、多次引入，随后在两个国家出现携带该质粒的三种STs（ST147、ST392、ST45）的大规模克隆暴发，表明该质粒进一步传播的风险很高，并且难治性感染有增加的可能性。
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