Daneshpour Nazanin, Rajabi Mahsa, Zafari Nima
Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran.
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Probiotics Antimicrob Proteins. 2025 Jul 11. doi: 10.1007/s12602-025-10645-9.
Obesity has emerged as a major global health concern, contributing to the development of many chronic illnesses and metabolic conditions. Recent studies underscore the critical role that gut bacteria play in controlling the body's metabolism, with Bifidobacterium species gaining prominence for their diverse effects on the management of obesity. This review considers the knowledge currently accessible about the processes that how Bifidobacterium affects obesity, extending beyond the conventional understanding of probiotics. We explore the probiotic characteristics of Bifidobacterium, which encompass the enhancement of gut homeostasis, the strengthening of intestinal barrier integrity, the mitigation of inflammation as a key factor in obesity pathogenesis, and various other widely recognized beneficial effects. In addition, we discuss the role of Bifidobacterium in metabolic functions and its effects on weight management and associated mechanisms. This review also addresses Bifidobacterium and the multiple elements that lead to obesity, including the interaction with dietary and nutritional elements, the effects of exercise and lifestyle choices, and the consideration of impacts from both the environment and genetics. The evidence and mechanisms presented highlight the beneficial role of Bifidobacterium in managing obesity; however, there remain significant gaps in our comprehensive understanding of its impact on obesity, which we have aimed to address in this review.
肥胖已成为全球主要的健康问题，它会引发多种慢性疾病和代谢紊乱。最近的研究强调了肠道细菌在控制人体新陈代谢中所起的关键作用，其中双歧杆菌因其对肥胖管理的多种作用而备受关注。本综述探讨了目前已知的双歧杆菌影响肥胖的机制，超越了对益生菌的传统认知。我们研究了双歧杆菌的益生菌特性，包括增强肠道内环境稳定、强化肠道屏障完整性、减轻炎症（肥胖发病机制中的关键因素）以及其他各种广为人知的有益作用。此外，我们还讨论了双歧杆菌在代谢功能中的作用及其对体重管理的影响和相关机制。本综述还探讨了双歧杆菌与导致肥胖的多个因素，包括与饮食和营养因素的相互作用、运动和生活方式选择的影响，以及环境和遗传因素的作用。文中提出的证据和机制突出了双歧杆菌在管理肥胖方面的有益作用；然而，我们对其对肥胖影响的全面理解仍存在重大差距，本综述旨在解决这些问题。
