Isennock Shannon, Elabiad Mohamad
Department of Pediatrics, Division of Neonatology, University of Tennessee Health Science Center, 853 Jefferson Ave, Memphis, TN, 38163, USA.
Regional One Health Hospital, 877 Jefferson Ave, Memphis, TN, 38103, USA.
Biol Trace Elem Res. 2025 Jul 11. doi: 10.1007/s12011-025-04742-7.
Iron deficiency anemia (IDA) has been associated with increased blood lead (BPb). Increased BPb in pregnancy has been associated with increased cord BPb. The association between IDA in pregnancy and cord PB levels has not been previously investigated. It is thus hypothesized that IDA in pregnancy results in increased cord BPb levels. Prospectively, cord blood, from term infants delivered in Memphis, TN, was tested for lead, manganese, mercury, and selenium. Maternal charts were retrospectively reviewed and subjects enrolled into two groups: IDA group with hemoglobin < 9 g/dL, 65 fl < MCV 75 fl, MCHC < 32 g/dL and controls with hemoglobin > 12 g/dL, 80 fl < MCV < 95 fl and MCHC > 34 g/dL. Exclusion criteria were chronic conditions, sickle cell disease, and thalassemia. Fifty-five infants were included, with 27 in the maternal anemia group and 28 in the control group. There were no significant differences between groups in maternal age, pregnancy histories, prenatal vitamin and iron intakes, or other morbidities. Pregnancies with anemia had significantly lower BPb and blood mercury (BHg) levels and significantly higher blood selenium (BSe) levels than those without anemia,0.24 (0.18,0.32) µg/L, 0.19(0.17,0.52), 184 ± 31 vs 0.33 (0.27,0.45), 0.55 (0.27,0.92), 160 ± 33, respectively. Conclusion: Pregnancies with anemia were associated with significantly higher cord BSe levels and lower BPb and BHg levels than pregnancies without anemia. Selenium consumption has been shown to lower BPb and BHg levels. This may explain our findings. Future studies are needed to investigate the role of selenium consumption as a protective agent against the transfer of heavy metals across the placenta.
缺铁性贫血（IDA）与血铅（BPb）升高有关。孕期血铅升高与脐血铅升高有关。孕期IDA与脐血铅水平之间的关联此前尚未得到研究。因此，有人提出假设，孕期IDA会导致脐血铅水平升高。前瞻性地，对田纳西州孟菲斯市足月分娩婴儿的脐带血进行了铅、锰、汞和硒检测。对产妇病历进行回顾性审查，将受试者分为两组：IDA组，血红蛋白<9 g/dL，平均红细胞体积（MCV）为65 fl<75 fl，平均红细胞血红蛋白浓度（MCHC）<32 g/dL；对照组，血红蛋白>12 g/dL，MCV为80 fl<95 fl，MCHC>34 g/dL。排除标准为慢性病、镰状细胞病和地中海贫血。共纳入55名婴儿，其中产妇贫血组27名，对照组28名。两组产妇在年龄、妊娠史、产前维生素和铁摄入量或其他疾病方面无显著差异。与无贫血的孕妇相比，贫血孕妇的血铅和血汞（BHg）水平显著降低，血硒（BSe）水平显著升高，分别为0.24（0.18,0.32）μg/L、0.19(0.17,0.52)、184±31和0.33（0.27,0.45）、0.55（0.27,0.92）、160±33。结论：与无贫血的孕妇相比，贫血孕妇的脐血BSe水平显著升高，血铅和血汞水平降低。已证明摄入硒可降低血铅和血汞水平。这可能解释了我们的研究结果。未来需要进行研究，以探讨摄入硒作为一种保护剂对重金属跨胎盘转运的作用。
