Zhou Qing, Zhang Baozhu, Chen Xi, Chen Qiuyan, Hao Lu
Central Laboratory People's Hospital of Baoan District The Second Affiliated Hospital of Shenzhen University Shenzhen China.
Department of Oncology People's Hospital of Baoan District The Second Affiliated Hospital of Shenzhen University Shenzhen China.
Food Sci Nutr. 2021 Mar 27;9(6):3039-3047. doi: 10.1002/fsn3.2261. eCollection 2021 Jun.
Few studies have examined the association of serum selenium with anemia-related indicators and risk of anemia. We conducted a cross-sectional analysis of 2,902 adults in 2003-2004 National Health and Nutrition Examination Survey database. Multivariable linear and logistic regression models were used to examine the association of serum selenium with anemia-related indicators and risk of anemia. The nonlinear relationship was analyzed using a generalized additive model with the smoothing plot. A total of 1,472 males and 1,430 females with a mean age of 61.94 ± 13.73 years were included. Compared with the lowest quintile, the highest quintile of serum selenium was associated with increased level of serum iron (β = 12.44, 95% confidence interval [CI]: 7.14, 17.75, < .001), mean corpuscular hemoglobin concentration (MCHC) (β = 0.14, 95%CI: 0.02, 0.26, = .020), and hemoglobin (β = 0.40, 95%CI: 0.19, 0.61, < .001), and decreased risk of anemia (odds ratio [OR] = 0.47, 95%CI: 0.28, 0.77, = .002). Furthermore, smoothed plots suggested the nonlinear relationships between serum selenium and MCHC, hemoglobin level, and risk of anemia. Interestingly, on the left of inflection point, serum selenium was associated with decreased risk of anemia (OR = 0.972, 95%CI: 0.960, 0.985, < .001), and then, the risk of anemia increased with increasing serum selenium concentration (OR = 1.011, 95%CI: 1.002, 1.021, = .023). Future large-scale, polycentric prospective studies should be conducted to verify our results.
很少有研究探讨血清硒与贫血相关指标及贫血风险之间的关联。我们对2003 - 2004年国家健康与营养检查调查数据库中的2902名成年人进行了横断面分析。使用多变量线性和逻辑回归模型来研究血清硒与贫血相关指标及贫血风险之间的关联。采用带有平滑图的广义相加模型分析非线性关系。共纳入1472名男性和1430名女性，平均年龄为61.94±13.73岁。与最低五分位数相比，血清硒最高五分位数与血清铁水平升高（β = 12.44，95%置信区间[CI]：7.14，17.75，P <.001）、平均红细胞血红蛋白浓度（MCHC）（β = 0.14，95%CI：0.02，0.26，P = 0.020）和血红蛋白（β = 0.40，95%CI：0.19，0.61，P <.001）相关，且贫血风险降低（比值比[OR] = 0.47，95%CI：0.28，0.77；P = 0.002）。此外，平滑图表明血清硒与MCHC、血红蛋白水平及贫血风险之间存在非线性关系。有趣的是，在拐点左侧，血清硒与贫血风险降低相关（OR = 0.972，95%CI：0.960，0.985，P <.001），然后，贫血风险随着血清硒浓度的增加而增加（OR = 1.011，95%CI：1.002，1.021，P = .023）。未来应开展大规模、多中心前瞻性研究以验证我们的结果。
