Huang Zirui, Pang Bo, Guo Tengfei, Yang Youlei, Cheng Xingbo, Yang Zhizhao, Mao Kezheng, Liu Zhendong, Qian Rongjun
Department of Neurosurgery, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China.
Department of Neurosurgery, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China.
PLoS One. 2025 Jul 11;20(7):e0324426. doi: 10.1371/journal.pone.0324426. eCollection 2025.
ZNF800 is a novel gene affecting the malignant progression of several cancers. However, the involvement of ZNF800 in the malignant evolution of lower-grade gliomas (LGG) and poor prognosis of patients remains unclear. This study comprehensively revealed the association between ZNF800 and LGG malignant progression by analyzing 958 clinical samples from multiple public databases. The mRNA and protein expression levels of ZNF800 were higher in LGG tissues than in non-LGG tissues and were associated with malignant clinical features associated with a poor prognosis. High ZNF800 expression was closely related to the infiltration of some immune cells, particularly CD8 + T cells and dendritic cell activation. ZNF800 was positively associated with several immune checkpoint genes, such as CD274 and PDCD1 encoding PD-1 and PD-L1, respectively. Moreover, knocking down ZNF800 can significantly inhibit the proliferation and invasion ability of glioma cells. Therefore, ZNF800 can be used as an effective biomarker for LGG diagnosis and prognosis and can provide a theoretical basis for potential targets of combined immunotherapy in patients with LGG.
ZNF800是一种影响多种癌症恶性进展的新基因。然而，ZNF800在低级别胶质瘤（LGG）恶性进展及患者预后不良中的具体作用仍不清楚。本研究通过分析来自多个公共数据库的958份临床样本，全面揭示了ZNF800与LGG恶性进展之间的关联。ZNF800的mRNA和蛋白质表达水平在LGG组织中高于非LGG组织，且与预后不良的恶性临床特征相关。ZNF800高表达与某些免疫细胞的浸润密切相关，尤其是CD8 + T细胞和树突状细胞活化。ZNF800与多个免疫检查点基因呈正相关，如分别编码PD-1和PD-L1的CD274和PDCD1。此外，敲低ZNF800可显著抑制胶质瘤细胞的增殖和侵袭能力。因此，ZNF800可用作LGG诊断和预后的有效生物标志物，并可为LGG患者联合免疫治疗的潜在靶点提供理论依据。
