Ge Lingcong, Trinh Thi Kim Hoang, Li Changning, Mayer Florian, Chin Jia Min, Chen Chun-Long, Reithofer Michael R
Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, Vienna 1090, Austria.
Vienna Doctoral School in Chemistry (DoSChem), University of Vienna, Währinger Str. 42, 1090 Vienna, Austria.
Nano Lett. 2025 Aug 6;25(31):12049-12058. doi: 10.1021/acs.nanolett.5c02998. Epub 2025 Jul 11.
N-Heterocyclic carbene (NHC) ligands, with strong metal-binding affinity, offer a robust platform for constructing organic-inorganic nanohybrids with high stability and tunable properties. However, achieving precise structural control in a simple manner remains challenging. Here, we report a one-pot synthesis of nanohybrids using self-assembling peptoids functionalized with histidine-2-ylidene, which simultaneously enable peptoid assembly and NHC-metal binding. Histidine-2-ylidene-functionalized peptoids were designed to self-assemble and provide NHC binding sites, while AuNPs served as the inorganic component due to NHCs' strong affinity for gold surfaces. The resulting peptoid-NHC@AuNPs form well-defined vesicles that are characterized by UV-vis spectroscopy, X-ray photoelectron spectroscopy, and electron microscopy. Importantly, the vesicle size and morphology can be tuned via the peptoid sequence or environmental conditions. Further experiments highlight the crucial role of the NHC sites in the formation and stabilization of these nanohybrids. This modular strategy offers a versatile route to fabricating functional NHC-based nanohybrids for potential applications in sensing.
N-杂环卡宾（NHC）配体具有很强的金属结合亲和力，为构建具有高稳定性和可调性质的有机-无机纳米杂化物提供了一个强大的平台。然而，以简单的方式实现精确的结构控制仍然具有挑战性。在此，我们报道了一种使用用亚胺基-2-咪唑功能化的自组装类肽一锅法合成纳米杂化物，这同时实现了类肽组装和NHC-金属结合。亚胺基-2-咪唑功能化的类肽被设计用于自组装并提供NHC结合位点，而由于NHC对金表面具有很强的亲和力，金纳米粒子（AuNPs）用作无机组分。所得的类肽-NHC@AuNPs形成了定义明确的囊泡，通过紫外可见光谱、X射线光电子能谱和电子显微镜对其进行了表征。重要的是，囊泡的大小和形态可以通过类肽序列或环境条件进行调节。进一步的实验突出了NHC位点在这些纳米杂化物的形成和稳定中的关键作用。这种模块化策略为制造功能性NHC基纳米杂化物提供了一条通用途径，可用于传感方面的潜在应用。
