Li Cong, Yue Xin, Gao Heqi, Meng QingXun, Qu Jiafei, Chen Yao, Ding Dan, Xin Jingrui, Shen Jing
Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, China; Department I of Endodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300041, China.
Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, China; International Dental Clinic, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300041, China.
Biomater Adv. 2025 Dec;177:214397. doi: 10.1016/j.bioadv.2025.214397. Epub 2025 Jun 30.
Periodontitis is a chronic infectious disease caused by plaque microorganisms, leading to the destruction of collagen fibers and alveolar bone absorption. Advanced stages of periodontitis require surgical intervention to regenerate periodontal tissues. Traditional guided tissue regeneration (GTR) membranes have limitations in promoting tissue regeneration, primarily due to insufficient antibacterial properties and inability to conform to various bone defect shapes. This study introduces an injectable hydrogel (MH-TTB@CSA) combining carboxymethyl chitosan, sodium alginate, minocycline, and TTB nanoparticles, enhanced by near-infrared (NIR) photothermal therapy. The hydrogel offers precise defect matching and exhibits strong antibacterial effects under 808 nm irradiation (50 °C). Additionally, minocycline's properties and NIR-induced mild photothermal treatment (40 °C) stimulate bone growth by upregulating alkaline phosphatase (ALP) and promoting mineralization. By adjusting TTB nanoparticle concentration and laser power, the hydrogel effectively switches between antibacterial and osteogenic modes. This creates an optimal microenvironment for bone regeneration, making it a promising approach for treating bone defects.
牙周炎是一种由菌斑微生物引起的慢性感染性疾病，会导致胶原纤维破坏和牙槽骨吸收。牙周炎的晚期需要手术干预来实现牙周组织再生。传统的引导组织再生（GTR）膜在促进组织再生方面存在局限性，主要是由于抗菌性能不足且无法适应各种骨缺损形状。本研究介绍了一种可注射水凝胶（MH-TTB@CSA），它由羧甲基壳聚糖、海藻酸钠、米诺环素和TTB纳米颗粒组成，并通过近红外（NIR）光热疗法得到增强。该水凝胶能精确匹配缺损，在808纳米照射（50°C）下表现出强大的抗菌效果。此外，米诺环素的特性和近红外诱导的温和光热处理（40°C）通过上调碱性磷酸酶（ALP）和促进矿化来刺激骨生长。通过调整TTB纳米颗粒浓度和激光功率，该水凝胶可在抗菌和成骨模式之间有效切换。这为骨再生创造了一个最佳的微环境，使其成为治疗骨缺损的一种有前景的方法。
