Bressan Rente Ferreira Marum Annete, Boveto Santamarina Aline, Andrade Pedro, Marçal Pessoa Ana Flávia, Vidal Dias Bruna, Meil Schimith Escrivão Maria Arlete
Paulista School of Medicine, Federal University of São Paulo - UNIFESP, São Paulo, SP 04021-001, Brazil; Instituto Medicina e Nutrição de Precisão, São Paulo, SP 01432-030, Brazil.
Laboratório de Produtos e Derivados Naturais, Laboratório de Investigação Médica-26 (LIM-26), Departamento de Cirurgia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 01246903, Brazil.
Clin Nutr ESPEN. 2025 Jul 9;69:225-232. doi: 10.1016/j.clnesp.2025.07.016.
BACKGROUND & AIMS: This study aimed to investigate the association between the homozygous fat mass and obesity-associated (FTO rs9939609) risk genotype and body weight, body mass index (BMI), and binge eating behavior in a women cross-sectional study. Specifically, it sought to assess whether the FTO polymorphism correlates with increased BMI and scores on the Binge Eating Scale (BES).
A cross-sectional study was conducted with 80 women who provided data on body weight, BMI, and BES scores. Genotypic analysis for the FTO rs9939609 gene was performed, grouping participants into three genotypes: TT (wild-type), AT (heterozygous), and AA (homozygous risk). Anthropometric measures were collected either in person or through self-reported methods. Statistical analyses included Kruskal-Wallis tests, Fisher's exact test, and logistic regression to assess associations between genotype and study outcomes.
The AA homozygous genotype was significantly associated with higher body weight and BMI compared to the TT and AT groups (p = 0.004 and p = 0.008, respectively). Moreover, AA carriers exhibited higher BES scores, indicating a greater predisposition to binge eating behavior (p = 0.043). Logistic regression revealed that the AA genotype had a higher odds ratio for elevated body weight, BMI, and BES scores compared to the TT genotype.
The FTO rs9939609 polymorphism, particularly the homozygous risk genotype (AA), is associated with increased body weight, BMI, and binge eating behavior in women. These findings highlight the genetic contribution to obesity and eating disorders, offering potential implications for personalized interventions targeting those at higher genetic risk.
Universidade Federal de São Paulo Ethics Committee (CEP-UNIFESP No.0565/2018).
本研究旨在通过一项女性横断面研究，调查纯合子脂肪量与肥胖相关基因（FTO rs9939609）风险基因型与体重、体重指数（BMI）及暴饮暴食行为之间的关联。具体而言，本研究旨在评估FTO基因多态性是否与BMI升高及暴饮暴食量表（BES）得分相关。
对80名女性进行了横断面研究，收集她们的体重、BMI和BES得分数据。对FTO rs9939609基因进行基因分型分析，将参与者分为三种基因型：TT（野生型）、AT（杂合子）和AA（纯合子风险型）。人体测量指标通过现场测量或自我报告的方式收集。统计分析包括Kruskal-Wallis检验、Fisher精确检验和逻辑回归，以评估基因型与研究结果之间的关联。
与TT组和AT组相比，AA纯合子基因型与更高的体重和BMI显著相关（分别为p = 0.004和p = 0.008）。此外，AA基因型携带者的BES得分更高，表明其暴饮暴食行为的倾向更大（p = 0.043）。逻辑回归显示，与TT基因型相比，AA基因型在体重、BMI和BES得分升高方面具有更高的优势比。
FTO rs9939609基因多态性，尤其是纯合子风险基因型（AA），与女性体重增加、BMI升高及暴饮暴食行为有关。这些发现突出了基因对肥胖和饮食失调的影响，为针对高遗传风险人群的个性化干预提供了潜在依据。
圣保罗联邦大学伦理委员会（CEP-UNIFESP No.0565/2018）。
