Department of Food Science and Nutrition, Keimyung University, Daegu, Korea (the Republic of).
Department of Food Science and Nutrition, Keimyung University, Daegu, Korea (the Republic of)
BMJ Open Diabetes Res Care. 2023 Nov 22;11(6):e003649. doi: 10.1136/bmjdrc-2023-003649.
The fat mass and obesity-associated () gene is a significant locus in obesity. However, the association between genetic variants and body composition has not been fully elucidated.
This observational study examined the associations of rs9939609 T>A with obesity and body composition markers in Koreans. A total of 6474 participants from the Korean Genome and Epidemiology Study were analyzed for their general characteristics, body composition and genotype with a sex-stratified approach.
Females with the obesity risk A allele showed significantly greater body weight, hip circumference, and body mass index and were at a 1.28-fold higher risk of obesity (95% CI=1.088 to 1.507) than those with the TT genotype. Analyses of body composition also showed that females with the A allele had a greater body fat mass and percentage, abdominal fat percentage, and degree of obesity, and this association and genetic variation and adiposity was observed in females, especially aged under 50 years. However, the effect of the variant allele on non-fat tissue markers was not evident in females and was not associated with any parameters examined in males.
The rs9939609 variant is associated with body composition in Koreans, especially body fat markers in females. These results support that the rs9939609 variant is a genetic risk factor in the etiology of obesity.
脂肪量和肥胖相关（）基因是肥胖的一个重要基因座。然而，基因变异与身体成分的关联尚未完全阐明。
本观察性研究在韩国人群中考察了 rs9939609 T>A 与肥胖和身体成分标志物的关联。在韩国基因组和流行病学研究中，共有 6474 名参与者按照性别分层的方法分析了他们的一般特征、身体成分和基因型。
肥胖风险等位基因 A 的女性体重、臀围和身体质量指数显著增加，肥胖风险是 TT 基因型女性的 1.28 倍（95%可信区间为 1.088 至 1.507）。对身体成分的分析也表明，携带 A 等位基因的女性体脂肪量和体脂百分比、腹部脂肪百分比和肥胖程度更大，这种关联和遗传变异与肥胖在女性中，尤其是在 50 岁以下的女性中更为明显。然而，该变异等位基因对女性非脂肪组织标志物的影响不明显，与男性检查的任何参数均无关。
rs9939609 变异与韩国人的身体成分有关，尤其是女性的体脂肪标志物。这些结果支持 rs9939609 变异是肥胖病因学中的遗传风险因素。
