Liu Vivian N, Huang David Roy, Alaa Aos, Hayhoe Benedict, El-Osta Austen
Department of Clinical Research, Menwell Ltd, Bronze Building, Floor 1, 105 Sumner Street, London, UK
Department of Clinical Research, Menwell Ltd, Bronze Building, Floor 1, 105 Sumner Street, London, UK.
BMJ Open. 2025 Jul 10;15(7):e094145. doi: 10.1136/bmjopen-2024-094145.
Non-specific symptoms of testosterone deficiency (TD) and lack of awareness impact diagnosis and appropriate treatment. This study aimed to characterise the awareness of key symptoms of TD in community-dwelling men and contextualise this against the reported prevalence of these symptoms.
Cross-sectional survey comprising 54 questions (including assessment of symptoms as per the qADAM questionnaire and where relevant, men's experiences while on TD treatment). The survey was distributed through online media channels, Prolific and academic networks.
Community-dwelling men in the UK.
Associations between age, participant demographics and a 'positive' qADAM score were assessed using logistic regression. A positive qADAM score was defined as self-rated 'poor' or 'terrible' libido or erection strength or rating 3 of the other questionnaire domains as 'poor' or 'terrible'.
Of 973 men, 49% indicated high likelihood of TD using qADAM scores-5% were formally diagnosed. Men over 50 years of age had 1.54-2.0 times higher odds of TD compared with men aged <40 (p<0.05). 31% reported low libido, 27% reported reduced erectile strength and 26% reported over three symptoms associated with TD. Despite this, 55% were unfamiliar with symptoms/signs associated with TD. Only 7% of individuals expressed satisfaction with their access to low testosterone resources in the UK. Key barriers to seeking medical advice or treatment included lack of awareness of symptoms (39%), financial costs (35%) and stigma surrounding hormonal health (29%).
Almost half of the responders exhibited a burden of TD-associated symptoms, but under 5% had a formal diagnosis. These findings suggest significant gaps between symptom awareness and access to treatment options.
睾酮缺乏(TD)的非特异性症状以及认知不足会影响诊断和恰当治疗。本研究旨在描述社区男性对TD关键症状的认知情况,并结合这些症状的报告患病率进行分析。
横断面调查,包含54个问题(包括根据qADAM问卷评估症状,以及在相关情况下,男性接受TD治疗时的经历)。该调查通过在线媒体渠道、Prolific和学术网络进行分发。
英国社区男性。
使用逻辑回归评估年龄、参与者人口统计学特征与“阳性”qADAM评分之间的关联。阳性qADAM评分定义为自我评定性欲或勃起强度为“差”或“极差”,或问卷其他领域中有3项评定为“差”或“极差”。
在973名男性中,49%根据qADAM评分显示TD可能性高,其中5%被正式诊断。50岁以上男性患TD的几率比40岁以下男性高1.54至2.0倍(p<0.05)。31%报告性欲低下,27%报告勃起强度下降,26%报告有三种以上与TD相关的症状。尽管如此,55%的人不熟悉与TD相关的症状/体征。在英国,只有7%的人对获取低睾酮资源表示满意。寻求医疗建议或治疗的主要障碍包括对症状缺乏认知(39%)、经济成本(35%)以及激素健康方面的污名化(29%)。
近一半的受访者表现出与TD相关的症状负担,但正式诊断的不到5%。这些发现表明症状认知与获得治疗选择之间存在显著差距。