Dargent F, Gardaz J P, Morel P, Suter P M, Junod A F
Clin Sci (Lond). 1985 Sep;69(3):279-86. doi: 10.1042/cs0690279.
To test the relative sensitivity of serotonin and propranolol pulmonary extraction measurements to changes in pulmonary vascular surface, we sequentially subjected anaesthetized dogs to left upper lobe atelectasis, left lung atelectasis and left pulmonary artery occlusion. We used a triple-indicator dilution technique to simultaneously measure the pulmonary extraction of serotonin and propranolol. After an initial series of measurements, dogs received dopamine and dextran to slightly increase pulmonary artery pressure and prevent further recruitment of capillaries. Left upper lobe atelectasis did not modify the pulmonary extraction of serotonin and propranolol. Left lung atelectasis provoked a reduction in the serotonin extraction ratio by only 4%, whereas the propranolol extraction ratio decreased by 13%. After left pulmonary artery occlusion, propranolol and serotonin extraction ratios decreased by 16% and 5% respectively. We conclude that the pulmonary extraction of propranolol is more sensitive to a decrease in pulmonary vascular surface than that of serotonin.
为了测试血清素和普萘洛尔肺摄取量测量对肺血管表面积变化的相对敏感性，我们依次对麻醉犬进行左上叶肺不张、左肺肺不张和左肺动脉闭塞。我们使用三重指示剂稀释技术同时测量血清素和普萘洛尔的肺摄取量。在最初一系列测量后，犬接受多巴胺和右旋糖酐以轻微增加肺动脉压并防止毛细血管进一步募集。左上叶肺不张未改变血清素和普萘洛尔的肺摄取量。左肺肺不张仅使血清素摄取率降低4%，而普萘洛尔摄取率降低13%。左肺动脉闭塞后，普萘洛尔和血清素摄取率分别降低16%和5%。我们得出结论，普萘洛尔的肺摄取量比血清素对肺血管表面积减少更敏感。
