Soler Zaida, Serrano-Gómez Gerard, Pons-Tarín Marc, Vega-Abellaneda Sara, Xie Zixuan, Manjón Isaac, Cognard Chloe, Varela Encarna, Yañez Francisca, Noguera-Segura Arnau, Roca-Bosch Melina, Manichanh Chaysavanh
Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
NPJ Biofilms Microbiomes. 2025 Jul 11;11(1):131. doi: 10.1038/s41522-025-00769-9.
Low consumption of whole grains, fruits, and vegetables has been identified as dietary risks for non-communicable diseases such as inflammatory bowel diseases (IBDs). We explore how individual and lifestyle factors influence these risks by shaping gut microbiome composition. 1001 healthy participants from all Spanish regions provided personal and dietary data at baseline, six, and twelve months, yielding 2475 responses. Gut microbiome data were analyzed for 500 healthy participants and 321 IBD patients. Our findings reveal that adherence to national dietary guidelines-characterized by diets rich in nuts, seeds, fruits, and vegetables-was associated with greater microbial diversity and reduced IBD-related dysbiosis. Finally, we observed variations in dietary patterns and microbiome diversity and composition across age groups, genders, regions, seasons, and transit time. This study is among the first to uncover dietary intake associated with IBD-related dysbiosis and to propose an interactive website for participants ( https://manichanh.vhir.org/POP/en ).
全谷物、水果和蔬菜摄入不足已被确定为炎症性肠病（IBD）等非传染性疾病的饮食风险因素。我们探讨个体和生活方式因素如何通过塑造肠道微生物群组成来影响这些风险。来自西班牙所有地区的1001名健康参与者在基线、六个月和十二个月时提供了个人和饮食数据，共得到2475份回复。对500名健康参与者和321名IBD患者的肠道微生物群数据进行了分析。我们的研究结果表明，遵循以富含坚果、种子、水果和蔬菜的饮食为特征的国家饮食指南，与更高的微生物多样性和减少的IBD相关生态失调有关。最后，我们观察到不同年龄组、性别、地区、季节和运输时间的饮食模式以及微生物群多样性和组成存在差异。本研究是首批揭示与IBD相关生态失调相关的饮食摄入量，并为参与者提出一个互动网站（https://manichanh.vhir.org/POP/en）的研究之一。
