Yin Rong, Li Man, Liu Chunrong, Pu Xue, Yi Wen, Wu Yunhong
Department of Nephrology, Hospital of Chengdu Office of People's Government of Xizang Autonomous Region (Hospital.C.X.), Chengdu, China.
Department of Radiology, Hospital of Chengdu Office of People's Government of Xizang Autonomous Region (Hospital.C.X.), Chengdu, China.
Sci Rep. 2025 Jul 11;15(1):25020. doi: 10.1038/s41598-025-08998-w.
To evaluate the connection between hemoglobin and chronic kidney disease in the adult population at high altitudes. 380 people who were at least 18 years old were invited to participate in this cross-sectional study, and they underwent interviews and examination for albuminuria, hematuria, estimated glomerular filtration rate (eGFR), hemoglobin, and several other essential variables from April 2021 to May 2021. The total prevalence of chronic kidney disease was 15%. During logistic regression analysis, we found that participants with elevated hemoglobin per 10 g/L had a 27% greater risk of chronic kidney disease (adjusted odds ratio (OR), 1.27; 95% confidence interval (CI), 1.09-1.48), and high-altitude polycythemia significantly increased the chronic kidney disease risk compared to the group without high-altitude polycythemia (OR, 2.44; 95% CI, 1.20-4.97, p = 0.019). Our observations further revealed a distinct J-shaped correlation between hemoglobin levels and chronic kidney disease, which had a threshold of approximately 213 g/L. The effect sizes and confidence intervals were 0.999 (0.979-1.018) below the threshold and 1.089 (1.029-1.154) above the threshold. Hemoglobin levels were significantly associated with chronic kidney disease in Tibetans. When the hemoglobin levels exceeded a certain value (approximately213 g/L), the risk of chronic kidney disease was significantly increased. High-altitude polycythemia was a risk factor for chronic kidney disease.
为评估高海拔地区成年人群中血红蛋白与慢性肾脏病之间的关联。邀请了380名年龄至少18岁的人参与这项横断面研究，他们在2021年4月至2021年5月期间接受了关于蛋白尿、血尿、估计肾小球滤过率（eGFR）、血红蛋白及其他几个重要变量的访谈和检查。慢性肾脏病的总患病率为15%。在逻辑回归分析中，我们发现血红蛋白每升高10 g/L的参与者患慢性肾脏病的风险高27%（调整优势比（OR）为1.27；95%置信区间（CI）为1.09 - 1.48），与无高原红细胞增多症的组相比，高原红细胞增多症显著增加了慢性肾脏病风险（OR为2.44；95% CI为1.20 - 4.97，p = 0.019）。我们的观察结果进一步揭示了血红蛋白水平与慢性肾脏病之间存在明显的J形相关性，其阈值约为213 g/L。阈值以下的效应量和置信区间为0.999（0.979 - 1.018），阈值以上为1.089（1.029 - 1.154）。血红蛋白水平与藏族人群的慢性肾脏病显著相关。当血红蛋白水平超过一定值（约213 g/L）时，慢性肾脏病风险显著增加。高原红细胞增多症是慢性肾脏病 的一个危险因素。
