Maguolo Alice, Jönsson Josefine, Perfilyev Alexander, Vaag Allan, Malchau Carlsen Emma, Nørgaard Kirsten, Franks Paul W, Renault Kristina M, Ling Charlotte
Epigenetics and Diabetes Unit, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden.
Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden.
Clin Epigenetics. 2025 Jul 11;17(1):123. doi: 10.1186/s13148-025-01923-y.
We assessed if fasting plasma insulin levels in pregnant women with obesity are associated with newborns' abdominal fat deposition (dual-energy X-ray absorptiometry) and with cord blood DNA methylation (450k array) in 232 mother-child pairs from the Treatment of Obese Pregnant women (TOP) study. Fasting maternal insulin at 18-20gw was associated with abdominal/total fat mass ratio in newborns independent of multiple potential confounders (β = 0.23[95%CI: 0.01; 0.45], P = 0.041) and with cord blood DNA methylation at CpG sites annotated to C11orf54 and RARB (FDR < 10%), both genes potentially involved in metabolic programming. In conclusion, maternal insulin levels in pregnancy were associated with adiposity traits and epigenetics in the offspring.
在肥胖孕妇治疗（TOP）研究中的232对母婴中，我们评估了肥胖孕妇的空腹血浆胰岛素水平是否与新生儿腹部脂肪沉积（双能X线吸收法）以及脐带血DNA甲基化（450k芯片）相关。孕18 - 20周时母体空腹胰岛素与新生儿腹部/总脂肪量比值相关，不受多种潜在混杂因素影响（β = 0.23[95%CI：0.01；0.45]，P = 0.041），并且与注释为C11orf54和RARB的CpG位点的脐带血DNA甲基化相关（FDR < 10%），这两个基因都可能参与代谢编程。总之，孕期母体胰岛素水平与后代的肥胖特征和表观遗传学相关。
