Jardin F, Genevray B, Brun-Ney D, Margairaz A
Crit Care Med. 1985 Dec;13(12):1009-12. doi: 10.1097/00003246-198512000-00004.
Intravenous dobutamine was used in ten patients requiring aggressive therapy for massive pulmonary embolism with circulatory failure. Except in one patient who rapidly died, a 30-min dobutamine infusion (8.3 +/- 2.7 micrograms/kg . min) increased both cardiac index (from 1.7 +/- 0.4 to 2.3 +/- 0.6 L/min . m2, p less than .001) and stroke index (from 16.6 +/- 6.7 to 21 +/- 5 ml/m2, p less than .01), and also reduced pulmonary vascular resistance. Additional hemodynamic improvement was observed until weaning from dobutamine, which was successfully completed 3.3 +/- 0.9 days after the start of infusion.
10例因大面积肺栓塞合并循环衰竭而需要积极治疗的患者使用了静脉注射多巴酚丁胺。除1例患者迅速死亡外，30分钟的多巴酚丁胺输注（8.3±2.7微克/千克·分钟）使心脏指数（从1.7±0.4升至2.3±0.6升/分钟·平方米，p<0.001）和每搏指数（从16.6±6.7升至21±5毫升/平方米，p<0.01）均升高，同时降低了肺血管阻力。在多巴酚丁胺撤机前观察到血流动力学进一步改善，输注开始后3.3±0.9天成功完成撤机。
