Delaval P M, Gillespie D J
Crit Care Med. 1985 Dec;13(12):1056-60. doi: 10.1097/00003246-198512000-00015.
Acute lung injury produced by paraquat causes progressive pulmonary insufficiency. To define the pattern of this injury, the sequence of changes in respiratory mechanics and pulmonary gas exchange was studied in eight mongrel dogs which received repetitive doses of paraquat intraperitoneally. Four other dogs served as controls. All dogs were studied while supine during halothane anesthesia. After baseline measurements, saline (control) or paraquat was administered and the studies repeated at 2, 4, 7, and 9 days. Control dogs showed no significant changes. Dogs receiving paraquat had reduced lung volume, decreased lung compliance with a shift of the static deflation pressure-volume curve downward and to the right, and hypoxemia which could not be entirely accounted for by an increased right-to-left intrapulmonary shunt. This study demonstrated that repeated doses of paraquat given intraperitoneally produced a pattern of acute lung injury in the dog which permitted the study of respiratory mechanics and gas exchange during progressive stages of lung injury.
百草枯所致急性肺损伤会导致进行性肺功能不全。为明确这种损伤的模式，对8只杂种犬进行了研究，这些犬经腹腔重复给予百草枯，观察其呼吸力学和肺气体交换的变化顺序。另外4只犬作为对照。所有犬在氟烷麻醉下仰卧位进行研究。在进行基线测量后，给予生理盐水（对照）或百草枯，并在第2、4、7和9天重复进行研究。对照犬未显示出明显变化。接受百草枯的犬肺容积减小，肺顺应性降低，静态放气压力-容积曲线向下和向右移位，并且存在低氧血症，而肺内右向左分流增加并不能完全解释这种低氧血症。本研究表明，经腹腔重复给予百草枯可在犬身上产生一种急性肺损伤模式，从而能够在肺损伤的进展阶段研究呼吸力学和气体交换。
