Akad Fawzy, Stan Cristinel Ionel, Zugun-Eloae Florin, Peiu Sorin Nicolae, Akad Nada, Crauciuc Dragos-Valentin, Moraru Marius Constantin, Popa Cosmin Gabriel, Gavril Liviu-Ciprian, Sufaru Roxana-Florentina, Preda Cristina, Mocanu Veronica
Department of Morpho-Functional Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Center for Obesity BioBehavioral Experimental Research, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Nutrients. 2025 Jun 27;17(13):2146. doi: 10.3390/nu17132146.
Gastric cancer remains a significant global health burden, with curative treatment relying on surgical resection, typically total or subtotal gastrectomy. However, the procedure frequently triggers acute metabolic and nutritional disturbances that may impact recovery. : This prospective study aimed to investigate whether the type of gastrectomy (total vs. subtotal) influences early postoperative biochemical and hematological alterations, with particular attention to nutritional impact. : A cohort of 295 patients (123 female, 172 male) who underwent gastrectomy for gastric cancer at the Institute of Oncology Iași (2023-2024) was evaluated. Laboratory parameters, including hemoglobin, hematocrit, lymphocyte and platelet counts, serum albumin, total protein, sodium, potassium, creatinine, and urea, were analyzed preoperatively and on postoperative day 14 using standard clinical methods. : Anemia was observed in over 90% of patients, irrespective of sex or procedure type. Electrolyte imbalances (notably hyponatremia and hypokalemia) and indicators of nutritional deficit (hypoalbuminemia, low creatinine) were highly prevalent, with a greater frequency among female patients. Total gastrectomy was associated with more severe biochemical and nutritional alterations compared to subtotal procedures. : Total gastrectomy significantly exacerbates early postoperative metabolic and nutritional derangements. These findings reinforce the need for proactive, personalized postoperative nutritional and electrolyte management strategies to support recovery and reduce complication risks.
胃癌仍然是一项重大的全球健康负担，其根治性治疗依赖于手术切除，通常是全胃切除术或胃次全切除术。然而，该手术经常引发急性代谢和营养紊乱，可能会影响恢复。：这项前瞻性研究旨在调查胃切除术的类型（全胃切除术与胃次全切除术）是否会影响术后早期的生化和血液学改变，尤其关注营养方面的影响。：对2023年至2024年在雅西肿瘤研究所接受胃癌胃切除术的295名患者（123名女性，172名男性）进行了评估。术前及术后第14天使用标准临床方法分析实验室参数，包括血红蛋白、血细胞比容、淋巴细胞和血小板计数、血清白蛋白、总蛋白、钠、钾、肌酐和尿素。：超过90%的患者出现贫血，无论性别或手术类型如何。电解质失衡（尤其是低钠血症和低钾血症）以及营养缺乏指标（低白蛋白血症、低肌酐）非常普遍，女性患者中更为常见。与胃次全切除术相比，全胃切除术与更严重的生化和营养改变相关。：全胃切除术会显著加剧术后早期的代谢和营养紊乱。这些发现强化了采取积极主动、个性化的术后营养和电解质管理策略以支持恢复并降低并发症风险的必要性。
