Center for Obesity BioBehavioral Experimental Research, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Department of Morpho-Functional Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Nutrients. 2024 May 14;16(10):1485. doi: 10.3390/nu16101485.
Gastric cancer (GC) remains a significant global health concern, ranking as the third leading cause of cancer-related deaths. Malnutrition is common in GC patients and can negatively impact prognosis and quality of life. Understanding nutritional issues and their management is crucial for improving patient outcomes. This cross-sectional study included 51 GC patients who underwent curative surgery, either total or subtotal gastrectomy. Various nutritional assessments were conducted, including anthropometric measurements, laboratory tests, and scoring systems such as Eastern Cooperative Oncology Group/World Health Organization Performance Status (ECOG/WHO PS), Observer-Reported Dysphagia (ORD), Nutritional Risk Screening-2002 (NRS-2002), Patient-Generated Subjective Global Assessment (PG-SGA), and Simplified Nutritional Appetite Questionnaire (SNAQ). Serum carcinoembryonic antigen (CEA) levels were significantly higher in the subtotal gastrectomy group. Nutritional assessments indicated a higher risk of malnutrition in patients who underwent total gastrectomy, as evidenced by higher scores on ORD, NRS-2002, and PG-SGA. While total gastrectomy was associated with a higher risk of malnutrition, no single nutritional parameter emerged as a strong predictor of surgical approach. PG-SGA predominantly identified malnutrition, with its occurrence linked to demographic factors such as female gender and age exceeding 65 years.
胃癌(GC)仍然是一个重大的全球健康问题,是癌症相关死亡的第三大主要原因。营养不良在 GC 患者中很常见,并可能对预后和生活质量产生负面影响。了解营养问题及其管理对于改善患者的结局至关重要。本横断面研究纳入了 51 例接受根治性手术(全胃切除术或胃大部切除术)的 GC 患者。进行了各种营养评估,包括人体测量学测量、实验室检查以及评分系统,如东部肿瘤协作组/世界卫生组织体能状态(ECOG/WHO PS)、观察者报告的吞咽困难(ORD)、营养风险筛查 2002(NRS-2002)、患者主观整体评估(PG-SGA)和简化营养食欲问卷(SNAQ)。胃大部切除术组的血清癌胚抗原(CEA)水平显著升高。营养评估表明,全胃切除术患者存在更高的营养不良风险,ORD、NRS-2002 和 PG-SGA 的评分更高。虽然全胃切除术与营养不良风险增加相关,但没有单一的营养参数可以作为手术方式的有力预测指标。PG-SGA 主要识别出营养不良,其发生与女性性别和年龄超过 65 岁等人口统计学因素有关。