炎症性肠病的全球、区域和国家负担，1990-2021：来自 2021 年全球疾病负担的见解。

Global, regional, and national burden of inflammatory bowel disease, 1990-2021: Insights from the global burden of disease 2021.

机构信息

Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.

Department of Critical Care Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang Province, China.

出版信息

Int J Colorectal Dis. 2024 Sep 7;39(1):139. doi: 10.1007/s00384-024-04711-x.

DOI:10.1007/s00384-024-04711-x

PMID:39243331

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11380638/

Abstract

PURPOSE

The prevalence of inflammatory bowel disease (IBD) is on the rise worldwide. We utilizes data from the Global Burden of Diseases (GBD) 2021 to analyze the national-level burden of IBD, trends in disease incidence, and epidemiological characteristics.

METHODS

Detailed information on IBD was gathered from 204 countries and territories spanning 1990 to 2021, sourced from the GBD 2021. Calculations were performed for incidence rates, mortality rates, disease-adjusted life years (DALYs), and estimated annual percentage changes (EAPCs). These trends were analyzed based on region, nationality, age, gender, and World Bank income level stratifications.

RESULTS

The global age-standardised incident rate (ASIR) of IBD increased from 4.22 per 100000 in 1990 to 4.45 per 100000 in 2021. However, the age-standardised mortality rate (ASMR) decreased from 0.60 per 100000 in 1990 to 0.52 per 100000 in 2021. Similarly, the age-standardised DALYs rate decreased from 21.55 per 100000 in 1990 to 18.07 per 100000 in 2021. Gender comparisons showed negligible differences in disease burden. The greatest increase in IBD-associated ASIR and ASMR occurred in World Bank upper-middle income region (EAPCs, 1.25) and World Bank high-income region (EAPCs, 1.00), respectively. Regionally, East Asia experienced the largest increase in ASIR (EAPCs, 2.89). Among 204 countries, China had the greatest increases in ASIR (EAPCs, 2.93), Netherlands had the highest ASMR in 2021 (2.21 per 100000).

CONCLUSIONS

Global incidence rate of IBD have been increasing from 1990 to 2021, while the DALYs and mortality have been decreasing. The escalating incident rates in select Asian regions deserves further attention.

摘要

目的

炎症性肠病（IBD）的患病率在全球范围内呈上升趋势。我们利用 2021 年全球疾病负担（GBD）的数据，分析 IBD 的国家层面负担、疾病发病率趋势和流行病学特征。

方法

详细的 IBD 信息来自 204 个国家和地区，时间跨度为 1990 年至 2021 年，来源于 GBD 2021。我们计算了发病率、死亡率、疾病调整生命年（DALY）和估计年百分比变化（EAPC）。根据地区、国籍、年龄、性别和世界银行收入水平进行分层，对这些趋势进行了分析。

结果

全球年龄标准化发病率（ASIR）从 1990 年的每 10 万人 4.22 例增加到 2021 年的每 10 万人 4.45 例。然而，年龄标准化死亡率（ASMR）从 1990 年的每 10 万人 0.60 例下降到 2021 年的每 10 万人 0.52 例。同样，年龄标准化 DALY 率从 1990 年的每 10 万人 21.55 例下降到 2021 年的每 10 万人 18.07 例。性别比较显示疾病负担差异可以忽略不计。IBD 相关 ASIR 和 ASMR 增加最多的分别是世界银行中上收入地区（EAPC，1.25）和世界银行高收入地区（EAPC，1.00）。在区域方面，东亚的 ASIR 增幅最大（EAPC，2.89）。在 204 个国家中，中国的 ASIR 增幅最大（EAPC，2.93），荷兰在 2021 年的 ASMR 最高（每 10 万人 2.21）。