Zarampouka Katerina, Tsiantas Christos, Stavropoulou Maria Athanasia, Efthymiadis Konstantinos, Theotokis Paschalis, Gargani Sofia, Vrettou Eleni, Koletsa Triantafyllia, Manthou Maria Eleni, Meditskou Soultana
Department of Pathology, Faculty of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Laboratory of Histology-Embryology, Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Cancers (Basel). 2025 Jun 24;17(13):2120. doi: 10.3390/cancers17132120.
: Gastric cancer (GC) is the fifth leading cause of cancer-related mortality. CLDN18.2 is a tight junction protein, expressed in gastric mucosa and is considered as a novel therapeutic target. Even though CLDN18.2 is associated with various components of the tumor microenvironment and the relation with clinical histopathological parameters has been widely studied, there is no sufficient data on the associations of CLDN18.2 expression and the components of the tumor microenvironment. This systematic review aims to gather and present all available data about the correlation of CLDN 18.2 expression and the tumor microenvironment. : The research questions were systematically formulated using the PICO model to ensure clarity and precision, and the PRISMA flow diagram was constructed to detail the study selection process. : Sixteen original articles were retrieved. The major finding of this study was the positive correlation between CLDN18.2 expression and CD8+ T cells, neutrophils and cancer-associated fibroblasts. No correlation was found between CLDN18.2 expression and Tregs and B cells. For the remaining components of the microenvironment, there are contradictory data about their correlation with the expression of CLDN18.2. : The tumor microenvironment plays a critical role in cancer progression and needs to be studied more thoroughly.
胃癌（GC）是癌症相关死亡的第五大主要原因。紧密连接蛋白18.2（CLDN18.2）是一种在胃黏膜中表达的紧密连接蛋白，被视为一种新的治疗靶点。尽管CLDN18.2与肿瘤微环境的各种成分相关，且其与临床组织病理学参数的关系已得到广泛研究，但关于CLDN18.2表达与肿瘤微环境成分之间的关联，尚无足够数据。本系统评价旨在收集并呈现所有关于CLDN18.2表达与肿瘤微环境相关性的现有数据。研究问题采用PICO模型进行系统制定，以确保清晰度和精确性，并构建PRISMA流程图以详细说明研究选择过程。检索到16篇原创文章。本研究的主要发现是CLDN18.2表达与CD8 + T细胞、中性粒细胞和癌症相关成纤维细胞之间呈正相关。未发现CLDN18.2表达与调节性T细胞（Tregs）和B细胞之间存在相关性。对于微环境的其余成分，关于它们与CLDN18.2表达的相关性存在相互矛盾的数据。肿瘤微环境在癌症进展中起关键作用，需要更深入地研究。
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