Deep Learning with Transfer Learning on Digital Breast Tomosynthesis: A Radiomics-Based Model for Predicting Breast Cancer Risk.

: Digital breast tomosynthesis (DBT) is a valuable imaging modality for breast cancer detection; however, its interpretation remains time-consuming and subject to inter-reader variability. This study aimed to develop and evaluate two deep learning (DL) models based on transfer learning for the binary classification of breast lesions (benign vs. malignant) using DBT images to support clinical decision-making and risk stratification. : In this retrospective monocentric study, 184 patients with histologically or clinically confirmed benign (107 cases, 41.8%) or malignant (77 cases, 58.2%) breast lesions were included. Each case underwent DBT with a single lesion manually segmented for radiomic analysis. Two convolutional neural network (CNN) architectures-ResNet50 and DenseNet201-were trained using transfer learning from ImageNet weights. A 10-fold cross-validation strategy with ensemble voting was applied. Model performance was evaluated through ROC-AUC, accuracy, sensitivity, specificity, PPV, and NPV. : The ResNet50 model outperformed DenseNet201 across most metrics. On the internal testing set, ResNet50 achieved a ROC-AUC of 63%, accuracy of 60%, sensitivity of 39%, and specificity of 75%. The DenseNet201 model yielded a lower ROC-AUC of 55%, accuracy of 55%, and sensitivity of 24%. Both models demonstrated relatively high specificity, indicating potential utility in ruling out malignancy, though sensitivity remained suboptimal. : This study demonstrates the feasibility of using transfer learning-based DL models for lesion classification on DBT. While the overall performance was moderate, the results highlight both the potential and current limitations of AI in breast imaging. Further studies and approaches are warranted to enhance model robustness and clinical applicability.