Dan Alexandra Oltea, Mocanu Carmen Luminița, Ștefănescu-Dima Alin Ștefan, Tănasie Andreea Cornelia, Maria Veronica Elena, Târtea Anca Elena, Bălășoiu Andrei Theodor
Department of Ophthalmology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Department of Physiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Diagnostics (Basel). 2025 Jul 3;15(13):1703. doi: 10.3390/diagnostics15131703.
This study aims to investigate the progression of retinal microvascular changes using OCTA in young T1DM patients without clinical signs of DR over a period of 3 years. : This prospective, longitudinal study analyzed OCT angiograms of T1DM patients without clinical signs of DR. It included 40 T1DM patients aged between 7 and 20 years old who formed the T1DM study group and 40 healthy subjects with similar demographic characteristics to the control group. The patients underwent comprehensive ophthalmic examination and OCT imaging using a Retina Wide protocol (6 × 6 mm). We analyzed the following microvascular retinal parameters: FAZ area, perimeter and circularity and superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density. : Statistically significant differences between the two groups were identified for the following parameters: the mean FAZ area at follow-up (0.38 ± 0.13) was larger than the mean FAZ area at baseline (0.31 ±0.11), the mean FAZ perimeter at follow-up (3.22 ± 0.75) was larger than the mean FAZ perimeter at baseline (2.61 ± 00.52) and the men FAZ circularity index at follow-up (0.47 ± 0.13) was decreased compared to the FAZ circularity index at baseline (0.56 ± 0.12). A statistically significant difference were also registered for the following parameter: the total SCP and DCP vessel density was decreased at follow-up (37.47 ± 1.57) compared to baseline (38.79 ± 1.00). : OCTA long-term monitoring of T1DM patients represents an effective method for tracking progressive changes in FAZ parameters and capillary plexus vascular density.
本研究旨在利用光学相干断层扫描血管造影（OCTA），对无糖尿病视网膜病变（DR）临床症状的年轻1型糖尿病（T1DM）患者进行为期3年的视网膜微血管变化进展情况调查。：这项前瞻性纵向研究分析了无DR临床症状的T1DM患者的OCT血管造影。研究纳入了40名年龄在7至20岁之间的T1DM患者，组成T1DM研究组，以及40名具有相似人口统计学特征的健康受试者作为对照组。患者接受了全面的眼科检查，并使用视网膜广角协议（6×6毫米）进行OCT成像。我们分析了以下视网膜微血管参数：黄斑无血管区（FAZ）面积、周长和圆形度，以及浅表毛细血管丛（SCP）和深部毛细血管丛（DCP）血管密度。：两组之间在以下参数上存在统计学显著差异：随访时的平均FAZ面积（0.38±0.13）大于基线时的平均FAZ面积（0.31±0.11），随访时的平均FAZ周长（3.22±0.75）大于基线时的平均FAZ周长（2.61±0.52），且随访时的FAZ圆形度指数（0.47±0.13）相比于基线时的FAZ圆形度指数（0.56±0.12）有所降低。在以下参数上也记录到了统计学显著差异：随访时SCP和DCP的总血管密度（37.47±1.57）相比于基线时（38.79±1.00）有所降低。：对T1DM患者进行OCTA长期监测是追踪FAZ参数和毛细血管丛血管密度渐进性变化的有效方法。
