Ouyang Jing, Yu Xiantong, Wang Mengjie, Wang Longfei, Li Zhao, Shi Chaojun, Li Hao, Yuan Yufeng, Zhou Jun, Chang Min
Key Laboratory of Optical Technology and Instrument for Medicine, Ministry of Education, College of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Key Laboratory of Crop Cultivation and Physiology, Agricultural College of Yangzhou University, Yangzhou 225009, China.
Sensors (Basel). 2025 Jun 23;25(13):3903. doi: 10.3390/s25133903.
Surface plasmon resonance (SPR) detection technology is playing an important role in various fields such as food safety and environmental monitoring due to its excellent stability and reliability. However, there is also a growing demand for higher sensitivity in SPR sensors. Therefore, this work developed an SPR sensor based on the synergistic effect of electric-field enhancement and adsorption enhancement by using amino acid-derived carbon dots (CDs). The results showed that the incorporation of amino acid CDs can generate a maximum electric-field enhancement of up to 6.44 × 10 V/m in the near-field region, which is 312% of that achieved by a bare gold film. And the adsorption kinetics results indicate that the active groups on the surface of amino acid CDs exhibit a notable adsorption enhancement effect for the target molecule (NaCl), with an adsorption capacity 335% higher than that of the bare gold film. This designed SPR sensor demonstrates a detection sensitivity of 167.28 a.u./RIU for NaCl solution, representing a 247.8% improvement compared to an SPR sensor without amino acid CDs under the same conditions. This SPR sensor shows promising potential for applications in biomedical and environmental detection fields.
表面等离子体共振（SPR）检测技术因其出色的稳定性和可靠性，在食品安全和环境监测等各个领域发挥着重要作用。然而，对SPR传感器更高灵敏度的需求也在不断增长。因此，这项工作通过使用氨基酸衍生的碳点（CDs），基于电场增强和吸附增强的协同效应开发了一种SPR传感器。结果表明，掺入氨基酸碳点可在近场区域产生高达6.44×10 V/m的最大电场增强，这是裸金膜实现的电场增强的312%。吸附动力学结果表明，氨基酸碳点表面的活性基团对目标分子（NaCl）表现出显著的吸附增强效应，吸附容量比裸金膜高335%。这种设计的SPR传感器对NaCl溶液的检测灵敏度为167.28 a.u./RIU，与相同条件下不含氨基酸碳点的SPR传感器相比提高了247.8%。这种SPR传感器在生物医学和环境检测领域显示出有前景的应用潜力。
