Quantification of 3D Kinematic Measurements for Knee Flexion and Tibial Rotation Using an IMU-Based Sensor and Ultrasound Imaging System: A Cadaveric Study.

Knee rotational stability is crucial for anterior cruciate ligament (ACL) procedures, yet, current clinical assessments are subjective and lack precision. This study evaluates the accuracy and repeatability of the GATOR system, developed by PreciX Pte Ltd. and integrating ultrasound with inertial measurement units (IMUs), against a reference IMU (Xsens DOTS) for measuring knee flexion and rotation in six cadaveric specimens secured in an Oxford Knee Jig. Two experiments were conducted: (A) knee flexion from 0° to 120°, and (B) internal/external rotation at 0°, 30°, 60°, 90°, and 120° flexion. Analysis using Bland-Altman plots, root mean square error (RMSE: 3.93° for internal rotation, 6.90° for external rotation), mean biases, and paired -tests (Bonferroni corrected) revealed that GATOR recorded lower peak flexion angles (91.49-114.65°) compared to the reference (110.31-118.49°). For rotation, internal rotation showed narrower limits of agreement than external rotation (biases: 1.91-6.88°). Over 60% of trials had errors < 5°, and 80% < 10°, indicating good agreement. Despite no isolated comparison of GATOR's ultrasound component, findings suggest reduced soft tissue artifact due to bone-referenced sensor alignment. With optimal placement (10-15 cm from the knee center), GATOR shows promise in ACL assessment and remote rehabilitation.