Quality of Life After Transradial Access in Cerebral Angiography: A SF-12 Analysis Using a Then-Test Design.

: Transradial access may affect health-related quality of life (QoL) in cerebral diagnostic angiography. However, its assessment is methodologically challenging, as repeated measurements can be influenced by response shift. To mitigate this bias, a retrospective cross-sectional study was designed using a then-test approach, allowing patients to reflect on their post procedural status at a single time point. : Quality of life was assessed using the 12-Item Short Form Health Survey (SF-12). A then-test approach was also employed, whereby patients were asked to retrospectively indicate whether they perceived their condition as worse following the procedure. The survey yielded Physical (PCS) and Mental Component Summary (MCS) scores, standardized to a mean of 50 (range of 0-100), with lower values indicating greater health-related limitations. Group differences were analyzed using the Mann-Whitney U test. Associations between PCS and MCS, respectively, and clinical variables were assessed using multiple linear regression models. : Forty patients underwent diagnostic cerebral angiography over a 15-month observation period. Applying a then-test design, Group A included the 12.5% (n = 5) of patients who reported feeling worse post-procedure while Group B comprised the remaining 87.5% (n = 35). QoL scores were significantly lower in Group A (Mdn = 28.6) compared to B (Mdn = 46.7) for both PCS scores ( = 0.007) and MCS scores (45.3 vs. 54.6, = 0.018). In the multiple linear regression analysis, no statistically significant associations were found between the PCS or MCS scores and any clinical variable, including age, sex, body mass index (BMI), procedure duration, dose area product, access site, prior neurosurgical history, and fluoroscopy time ( > 0.05). : Transradial access for diagnostic cerebral angiography may affect QoL, as assessed using the SF-12 questionnaire. Applying the then-test approach, the group of patients who reported feeling worse after the procedure (12.5%) showed significantly lower physical and mental health scores. These findings underscore the need for prospective studies to further investigate patient-reported outcomes.