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蛋白质在纳米和微粒上的吸附：取决于颗粒的形态和物理化学性质及其对颗粒-细胞相互作用的影响。

Protein Adsorption on Nano- and Microparticles: Dependence on Morphological and Physicochemical Properties of Particles and Effect on Particle-Cell Interactions.

作者信息

Gerasimovich Evgeniia, Karaulov Alexander, Nabiev Igor, Sukhanova Alyona

机构信息

Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 115409 Moscow, Russia.

Department of Clinical Immunology and Allergology, Institute of Molecular Medicine, Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia.

出版信息

Nanomaterials (Basel). 2025 Jul 1;15(13):1013. doi: 10.3390/nano15131013.

DOI:10.3390/nano15131013
PMID:40648720
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12250702/
Abstract

Engineered nano- and microparticles are considered as promising tools in biomedical applications, such as imaging, sensing, and drug delivery. Protein adsorption on these particles in biological media is an important factor affecting their properties, cellular interactions, and biological fate. Understanding the parameters determining the efficiency and pattern of protein adsorption is crucial for the development of effective biocompatible particle-based applications. This review focuses on the influence of the morphological and physicochemical properties of particles on protein adsorption, including the pattern and amount of the adsorbed protein species, as well as the relative abundance of proteins with specific functions or physicochemical parameters. The effects of functionalization of the particle surface with polyethylene glycol, zwitterions, zwitterionic polymers, or proteins on the subsequent protein adsorption are analyzed. In addition, the dependences of protein adsorption on the protein species, biological buffers, fluids, tissues, and other experimental conditions are looked into. The influence of protein adsorption on the targeting efficiency of particle-based delivery systems is also discussed. Finally, the effect of the adsorbed protein corona on the interaction of the engineered micro- and nanoparticles with cells and the roles of specific proteins adsorbed on the particle surface in the recognition of the particles by the immune system are considered.

摘要

工程化纳米和微粒被视为生物医学应用中有前景的工具，如成像、传感和药物递送。这些微粒在生物介质中的蛋白质吸附是影响其性质、细胞相互作用和生物命运的重要因素。了解决定蛋白质吸附效率和模式的参数对于开发有效的基于微粒的生物相容性应用至关重要。本综述重点关注微粒的形态和物理化学性质对蛋白质吸附的影响，包括吸附蛋白质种类的模式和数量，以及具有特定功能或物理化学参数的蛋白质的相对丰度。分析了用聚乙二醇、两性离子、两性离子聚合物或蛋白质对微粒表面进行功能化对后续蛋白质吸附的影响。此外，还研究了蛋白质吸附对蛋白质种类、生物缓冲液、液体、组织和其他实验条件的依赖性。还讨论了蛋白质吸附对基于微粒的递送系统靶向效率的影响。最后，考虑了吸附的蛋白质冠对工程化微米和纳米粒子与细胞相互作用的影响，以及吸附在微粒表面的特定蛋白质在免疫系统识别微粒中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/b0366036fa55/nanomaterials-15-01013-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/aa34f5891610/nanomaterials-15-01013-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/b5e085c14f92/nanomaterials-15-01013-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/c2d0f336ee2b/nanomaterials-15-01013-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/1086a2fe4e4a/nanomaterials-15-01013-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/9118e77b80ac/nanomaterials-15-01013-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/6e8373371637/nanomaterials-15-01013-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/18cf84344a27/nanomaterials-15-01013-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/b0366036fa55/nanomaterials-15-01013-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/aa34f5891610/nanomaterials-15-01013-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/b5e085c14f92/nanomaterials-15-01013-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/c2d0f336ee2b/nanomaterials-15-01013-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/1086a2fe4e4a/nanomaterials-15-01013-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/9118e77b80ac/nanomaterials-15-01013-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/6e8373371637/nanomaterials-15-01013-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/18cf84344a27/nanomaterials-15-01013-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/125a/12250702/b0366036fa55/nanomaterials-15-01013-g008.jpg

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本文引用的文献

[1]
Anticancer Nanoparticle Carriers of the Proapoptotic Protein Cytochrome .

Pharmaceutics. 2025-2-26

[2]
Protein Corona of Nanoparticles: Isolation and Analysis.

Chem Bio Eng. 2024-10-3

[3]
Machine Learning Enables Comprehensive Prediction of the Relative Protein Abundance of Multiple Proteins on the Protein Corona.

Research (Wash D C). 2024-9-25

[4]
Interaction of Serum and Plasma Proteins with Polyelectrolyte Microparticles with Core/Shell and Shell-Only Structures.

ACS Omega. 2024-6-28

[5]
Intermolecular Electrostatic Interactions in Cytochrome Protein Monolayer on Montmorillonite Alumosilicate Surface: A Positive Cooperative Effect.

Int J Mol Sci. 2024-6-21

[6]
A multifunctional protein pre-coated metal-organic framework for targeted delivery with deep tissue penetration.

Nanoscale. 2024-8-13

[7]
Nanoplastic Size and Surface Chemistry Dictate Decoration by Human Saliva Proteins.

ACS Appl Mater Interfaces. 2024-5-22

[8]
Advancing Analysis of Biomolecular Corona: Opportunities and Challenges in Utilizing Field-Flow Fractionation.

ACS Bio Med Chem Au. 2024-3-21

[9]
Pre-coating cRGD-modified bovine serum albumin enhanced the anti-tumor angiogenesis of siVEGF-loaded chitosan-based nanoparticles by manipulating the protein corona composition.

Int J Biol Macromol. 2024-5

[10]
Phospholipid Type Regulates Protein Corona Composition and Performance of Lipid Nanodiscs.

Mol Pharm. 2024-5-6

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