Jarkman S, Skoog K O, Nilsson S E
Doc Ophthalmol. 1985 Oct 15;60(4):375-82. doi: 10.1007/BF00158927.
Low and moderate intravenous doses of trichloroethylene, methylchloroform, and halothane dissolved in a lipid emulsion (Intralipid) were given to cynomolgus monkeys. The DC electroretinogram (ERG) and the standing potential of the eye (SP) were recorded directly with corneal contact lenses, very stable calomel electrodes, and under very constant general anesthesia. Even low doses of the substances (close to the hygienic threshold limit values in Sweden) clearly provoked slow variations with time in the amplitude of the c-wave of the ERG and in the SP level. Both potentials are generated mainly in the pigment epithelium. It is suggested that the effects reflect a direct influence of the chemicals upon the metabolism of the pigment epithelium or on the cell membrane. Thus the method used is a highly sensitive measure of effects of certain halogenated hydrocarbons on structures belonging to the central nervous system.
将低剂量和中等剂量的三氯乙烯、甲基氯仿和氟烷溶解在脂质乳剂（英脱利匹特）中，静脉注射给食蟹猴。使用角膜接触镜、非常稳定的甘汞电极，并在非常恒定的全身麻醉下，直接记录直流视网膜电图（ERG）和眼的静息电位（SP）。即使是低剂量的这些物质（接近瑞典的卫生阈值限值），也明显引起ERG的c波振幅和SP水平随时间的缓慢变化。这两种电位主要在色素上皮细胞中产生。提示这些效应反映了化学物质对色素上皮细胞代谢或细胞膜的直接影响。因此，所使用的方法是一种高度敏感的测量某些卤代烃对属于中枢神经系统结构影响的方法。
