Price P J, Hassett C M, Mansfield J I
In Vitro. 1978 Mar;14(3):290-3. doi: 10.1007/BF02616038.
Three chlorinated hydrocarbons, proposed or already in use as industrial substitutes for the hydrocarbon trichloroethylene, were tested for in vitro transforming potential in a Fischer rat embryo cell system (F1706), which previously has been shown to be sensitive to transformation by chemical carcinogens. Trichloroethylene and the three substitutes (1, 1, 1 trichloroethane, tetrachloroethylene and methylene chloride) all were found to induce transformation, the three substitutes being equal or more efficient transforming agents.
三种作为烃类三氯乙烯的工业替代品已被提出或已在使用的氯代烃，在费希尔大鼠胚胎细胞系统（F1706）中进行了体外转化潜能测试，该系统先前已被证明对化学致癌物的转化敏感。三氯乙烯和这三种替代品（1,1,1 - 三氯乙烷、四氯乙烯和二氯甲烷）均被发现可诱导转化，这三种替代品是同等或更有效的转化剂。
