Duelo Adriana, Sánchez-Pérez Sònia, Pellicer-Roca Salvador, Sánchez-Buxens Sara, Comas-Basté Oriol, Latorre-Moratalla M Luz, Vidal-Carou M Carmen
Departament de Nutrició, Ciències de l'Alimentació i Gastronomia, Campus de l'Alimentació de Torribera, Universitat de Barcelona (UB), 08921 Santa Coloma de Gramenet, Spain.
Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB), Universitat de Barcelona (UB), Av. Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain.
J Clin Med. 2025 Jun 27;14(13):4573. doi: 10.3390/jcm14134573.
: Diamine oxidase (DAO) deficiency can lead to excessive histamine absorption at the intestinal level, triggering symptoms that affect the gastrointestinal, neurological, dermatological, respiratory, circulatory, and musculoskeletal systems. This condition, known as histamine intolerance, is more prevalent in women. While serum DAO levels have been observed to increase during pregnancy in healthy women, there is a lack of in-depth studies evaluating the relationship between pregnancy, DAO activity, and histamine intolerance symptoms. This is the first study to assess serum DAO activity before, during, and after pregnancy, as well as the evolution of histamine intolerance symptoms in women diagnosed with this condition. Due to low histamine, diets are quite restrictive, no dietary intervention was considered for pregnant women. : This prospective observational study used an assessment questionnaire to evaluate the presence or absence of histamine-related symptoms in 30 adult women with histamine intolerance before, during, and after pregnancy. Serum DAO activity was also measured at the three time points. : Nearly all women (27 out of 30) experienced symptom improvement during pregnancy ( < 0.001). Specifically, at least 77% of women reported a marked reduction in flatulence, bloating, headache, rhinorrhea, flushing, pruritus, hypotonia, or muscle pain. Concurrently, the DAO activity significantly increased 11-fold from the baseline, coinciding with symptom relief. At two months postpartum, symptoms tended to reappear, accompanied by a significant decrease in DAO activity in all participants. : This first-of-its-kind observational study demonstrates an improvement in histamine intolerance symptoms and an increase in serum DAO activity during pregnancy. The pronounced symptom relief suggests that restrictive diets, such as low-histamine diets, may not be necessary during pregnancy. Further research is required to confirm these novel findings.
二胺氧化酶（DAO）缺乏会导致肠道对组胺的吸收过多，引发影响胃肠、神经、皮肤、呼吸、循环和肌肉骨骼系统的症状。这种情况被称为组胺不耐受，在女性中更为普遍。虽然观察到健康女性在孕期血清DAO水平会升高，但缺乏深入研究来评估怀孕、DAO活性和组胺不耐受症状之间的关系。这是第一项评估女性在怀孕前、孕期和产后血清DAO活性以及被诊断为此病的女性组胺不耐受症状演变情况的研究。由于组胺含量低，饮食限制颇多，未考虑对孕妇进行饮食干预。 这项前瞻性观察研究使用一份评估问卷，来评估30名患有组胺不耐受的成年女性在怀孕前、孕期和产后是否存在与组胺相关的症状。还在这三个时间点测量了血清DAO活性。 几乎所有女性（30名中的27名）在孕期症状都有所改善（<0.001）。具体而言，至少77%的女性报告肠胃胀气、腹胀、头痛、流鼻涕、脸红、瘙痒、肌张力减退或肌肉疼痛明显减轻。与此同时，DAO活性从基线显著增加了11倍，与症状缓解同时出现。产后两个月时，症状往往会再次出现，所有参与者的DAO活性都显著下降。 这项同类首创的观察性研究表明，孕期组胺不耐受症状有所改善，血清DAO活性增加。明显的症状缓解表明，孕期可能无需低组胺饮食等限制性饮食。需要进一步研究来证实这些新发现。
