Meng Lingdong, Tao Shouxuan, Wang Liyao, Cao Yu, Hou Jianhua, Wang Chengyin
Hemodialysis Center of Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou 225000, China.
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225000, China.
Molecules. 2025 Jun 25;30(13):2729. doi: 10.3390/molecules30132729.
The g-CN/TiO intercalation composite material was successfully synthesized and used as the adsorbent in the hemoperfusion device. Then, the cytotoxicity and hemolysis rate were studied. The experimental results proved that g-CN/TiO was non-toxic to cells and would not cause hemolysis. The adsorption and removal performance of the composite material for bilirubin (BR) was explored as well. The maximum adsorption capacity for BR was 850 mg·g. Compared with the chemical hemoperfusion adsorbent coconut shell activated carbon (AC), the g-CN/TiO material presented excellent adsorption performance. Furthermore, SEM, infrared spectroscopy, XPS and other characterizations results indicated that g-CN/TiO has an effective adsorption effect on bilirubin, and the main adsorption mechanism is chemical adsorption. This study demonstrates that g-CN/TiO may be a potential adsorbent for hemoperfusion in the treatment of hyperbilirubinemia.
成功合成了g-CN/TiO插层复合材料，并将其用作血液灌流装置中的吸附剂。然后，研究了其细胞毒性和溶血率。实验结果证明g-CN/TiO对细胞无毒且不会引起溶血。还探究了该复合材料对胆红素（BR）的吸附和去除性能。其对BR的最大吸附容量为850 mg·g。与化学血液灌流吸附剂椰壳活性炭（AC）相比，g-CN/TiO材料表现出优异的吸附性能。此外，扫描电子显微镜、红外光谱、X射线光电子能谱等表征结果表明，g-CN/TiO对胆红素具有有效的吸附作用，主要吸附机制为化学吸附。本研究表明，g-CN/TiO可能是治疗高胆红素血症血液灌流的潜在吸附剂。
