College of Agricultural Science and Engineering, Liaocheng University, Liaocheng, Shandong 252000, P. R. China.
J Agric Food Chem. 2023 Jun 7;71(22):8297-8316. doi: 10.1021/acs.jafc.3c00786. Epub 2023 May 30.
Hydrazides are present in many bioactive molecules and exhibit a variety of biological activities, such as insecticidal, herbicidal, antifungal, antitumor, and antiviral effects. In this Review, we review the application of hydrazide and its derived structures in the agricultural fungicidal field, including monohydrazides, diacylhydrazines, hydrazide-hydrazones, and sulfonyl hydrazides. In addition, the antifungal mechanism of action of the hydrazide derivatives was analyzed and summarized, mainly involving succinate dehydrogenase inhibitors, laccase inhibitors, and targeting plasma membranes. Finally, based on the structural analysis of the novel fungicidal lead compounds, the structure-activity relationship of the hydrazide derivatives was constructed and the development trend of hydrazide structures in fungicidal applications was prospected. It is hoped that this Review can provide some significant guidance for the development of new hydrazide fungicides in the future.
酰腙类化合物广泛存在于许多具有生物活性的分子中，表现出多种生物活性，如杀虫、除草、杀菌、抗肿瘤和抗病毒作用。在本综述中，我们综述了酰腙及其衍生结构在农业杀菌领域的应用，包括单酰腙、二酰腙、腙-腙、磺酰腙。此外，还分析和总结了酰腙衍生物的抗真菌作用机制，主要涉及琥珀酸脱氢酶抑制剂、漆酶抑制剂和靶向质膜。最后，基于新型杀菌先导化合物的结构分析，构建了酰腙衍生物的构效关系，并展望了酰腙结构在杀菌应用中的发展趋势。希望本综述能为今后新型酰腙类杀菌剂的开发提供一些有意义的指导。
