Kazimierska-Drobny Katarzyna, Szala Grzegorz, Musiał Janusz, Macko Marek, Karasiewicz Tomasz, Lewandowski Jakub
Faculty of Mechatronics, Kazimierz Wielki University, Mikolaj Kopernik 1 Street, 85-074 Bydgoszcz, Poland.
Faculty of Material Engineering, Kazimierz Wielki University, Mikolaj Kopernik 1 Street, 85-074 Bydgoszcz, Poland.
Materials (Basel). 2025 Jun 23;18(13):2969. doi: 10.3390/ma18132969.
The aim of the study was to assess the mechanical and material properties of porous titanium capsules, produced by 3D printing via the DMLS (Direct Metal Laser Sintering) technique based on their potential application as carriers for anticancer drugs. The study used capsules made from the Ti-6Al-4V alloy, and analyzes the impact of geometric parameters, structural features, and printing angles (0°, 45°, and 90°) on their compressive strength. A total of 36 capsules were tested, 18 of type KTD and 18 of type KTM, each in two loading directions. The surface roughness and damage characteristics resulting from mechanical loading have also been evaluated. Statistical analysis of the results was performed using Student's -test. The results show that the capsules printed at an angle of 45° are characterized by the highest compressive strength, while their resistance significantly exceeds the values typical of human bone tissue. Additionally, the observed damage does not lead to the formation of sharp edges or loose fragments, which confirms the safety of their use in the body. The high surface roughness promotes tissue integration and limits capsule migration after implantation. The analyses confirm the potential of 3D-printed titanium capsules as effective and safe drug carriers in personalized anticancer therapy.
本研究的目的是基于其作为抗癌药物载体的潜在应用，评估通过直接金属激光烧结（DMLS）技术3D打印制备的多孔钛胶囊的力学和材料性能。该研究使用了由Ti-6Al-4V合金制成的胶囊，并分析了几何参数、结构特征和打印角度（0°、45°和90°）对其抗压强度的影响。总共测试了36个胶囊，其中18个KTD型和18个KTM型，每个胶囊在两个加载方向上进行测试。还评估了机械加载导致的表面粗糙度和损伤特征。使用学生t检验对结果进行统计分析。结果表明，以45°角打印的胶囊具有最高的抗压强度，其抗性明显超过人体骨组织的典型值。此外，观察到的损伤不会导致尖锐边缘或松散碎片的形成，这证实了它们在体内使用的安全性。高表面粗糙度促进组织整合并限制植入后胶囊的迁移。分析证实了3D打印钛胶囊在个性化抗癌治疗中作为有效且安全的药物载体的潜力。
