Sanders V M, White K L, Shopp G M, Munson A E
Drug Chem Toxicol. 1985;8(5):357-72. doi: 10.3109/01480548509041064.
The purpose of this study was to assess the immunological effects of 1,1,2-trichloroethane (TCE) on random-bred CD-1 mice following 14 and 90 days of oral exposure. A toxicological evaluation conducted at the same time revealed the target organs to be the liver of both sexes and the erythroid elements of the females. The 14-day immunological range-finding study in males exposed to doses 1/10 and 1/100 the LD50 (38 and 3.8 mg/kg) revealed no alterations in either humoral or cell-mediated immune status. Following 90 days of exposure in the drinking water (4.4., 46, and 305 mg/kg for males and 3.9, 44, and 384 mg/kg for females), a more detailed series of immunological parameters was assessed. Cell-mediated immunity was unaltered in both sexes, while humoral immune status was depressed in both sexes, particularly when determined by hemagglutination titers. Macrophage function was depressed only in the males as indicated by the ability of thioglycolate-recruited peritoneal exudate cells (PEC) to phagocytize sheep erythrocytes (sRBC).
本研究的目的是评估1,1,2-三氯乙烷（TCE）经口暴露14天和90天后对随机繁殖的CD-1小鼠的免疫效应。同时进行的毒理学评估显示，靶器官为两性的肝脏以及雌性的红系成分。在暴露于1/10和1/100 LD50（38和3.8 mg/kg）剂量的雄性小鼠中进行的14天免疫范围查找研究显示，体液免疫或细胞介导的免疫状态均未改变。在饮用水中暴露90天后（雄性为4.4、46和305 mg/kg，雌性为3.9、44和384 mg/kg），评估了一系列更详细的免疫参数。两性的细胞介导免疫均未改变，而两性的体液免疫状态均受到抑制，特别是通过血凝滴度测定时。如巯基乙酸招募的腹腔渗出细胞（PEC）吞噬绵羊红细胞（sRBC）的能力所示，仅雄性的巨噬细胞功能受到抑制。
