Kauffmann B M, White K L, Sanders V M, Douglas K A, Sain L E, Borzelleca J F, Munson A E
Environ Health Perspect. 1982 Apr;44:147-51. doi: 10.1289/ehp.8244147.
Chloral hydrate has been found in our drinking water supplies at levels up to 5 micrograms/1. The purpose of this study was to evaluate the functional status of the immune system in random-bred CD-1 mice exposed to chloral hydrate for 14 and 90 days. Male mice, following 14 or 90 days of exposure to 1/10 and 1/100 the actual oral LD50, exhibited no alterations in either humoral or cell-mediated immunity. However, female mice exposed for 90 days to chloral hydrate in the drinking water demonstrated a significant depression in humoral immune function. This depression was observed when spleen cells from exposed mice were evaluated for their ability to produce antibody against sheep erythrocytes. These females did not demonstrate any changes in cell-mediated immune status.
在我们的饮用水供应中发现了水合氯醛，含量高达5微克/升。本研究的目的是评估随机繁殖的CD-1小鼠在暴露于水合氯醛14天和90天后免疫系统的功能状态。雄性小鼠在暴露于实际口服半数致死量的1/10和1/100达14天或90天后，体液免疫和细胞介导免疫均未出现改变。然而，饮用含氯醛水90天的雌性小鼠体液免疫功能显著降低。当评估暴露小鼠的脾细胞产生抗绵羊红细胞抗体的能力时，观察到了这种降低。这些雌性小鼠的细胞介导免疫状态未显示任何变化。
