White K L, Sanders V M, Barnes D W, Shopp G M, Munson A E
Drug Chem Toxicol. 1985;8(5):333-55. doi: 10.3109/01480548509041063.
1,1,2-Trichloroethane (TCE) was administered to male and female CD-1 mice to evaluate its effect on standard toxicological parameters. Following determination of the acute LD50 (378 mg/kg in males and 491 mg/kg in females), and a 14-day range-finding study, a 90-day drinking water study was performed in which the doses consumed were 4.4, 46, and 305 mg/kg for males and 3.9, 44, and 384 mg/kg for females. The liver was a target of TCE toxicity in both sexes as demonstrated by dose-dependent alterations in hepatic microsomal enzyme activities and serum enzyme levels. The erythroid element of the female mice was also affected, as indicated by significantly decreased hematocrit and hemoglobin levels.
将1,1,2-三氯乙烷（TCE）给予雄性和雌性CD-1小鼠，以评估其对标准毒理学参数的影响。在确定急性半数致死剂量（雄性为378 mg/kg，雌性为491 mg/kg）后，进行了一项为期14天的预试验研究，之后开展了一项为期90天的饮用水研究，雄性小鼠摄入的剂量分别为4.4、46和305 mg/kg，雌性小鼠摄入的剂量分别为3.9、44和384 mg/kg。肝脏是两性中TCE毒性的靶器官，肝微粒体酶活性和血清酶水平的剂量依赖性改变证明了这一点。雌性小鼠的红细胞成分也受到影响，表现为血细胞比容和血红蛋白水平显著降低。
