Kowalska Klaudia, Skwarek Ewa
Department of Radiochemistry and Environmental Chemistry, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University, 3 Maria Curie-Sklodowska Sq., 20-031 Lublin, Poland.
Materials (Basel). 2025 Jun 25;18(13):3011. doi: 10.3390/ma18133011.
The present study describes the mechanochemical synthesis and physicochemical characterization of a novel composite material composed of yellow clay, hydroxyapatite, and L. The synthesis was carried out using a solvent-free, energy-efficient mechanochemical method. The composite was analyzed for its toxicity, particle size distribution, release of bioactive compounds, surface morphology, structural features, and electrokinetic properties. UV-VIS spectrophotometry revealed that the release of bioactive substances was approximately 1.5 to 3 times higher in the composite compared to control samples. Particle size analysis indicated a wide distribution ranging from 350 to 1300 nm. Nitrogen adsorption-desorption (ASAP) confirmed the porous nature of the material, while SEM and FTIR analyses verified the successful incorporation of all components. Electrokinetic studies showed zeta potential values ranging from +15 mV to -32 mV, indicating varying colloidal stability. The proposed composite demonstrates promising potential as a carrier of biologically active substances for pharmaceutical and cosmetic applications.
本研究描述了一种由黄土、羟基磷灰石和L组成的新型复合材料的机械化学合成及物理化学表征。合成采用无溶剂、节能的机械化学方法进行。对该复合材料的毒性、粒度分布、生物活性化合物释放、表面形态、结构特征和电动性质进行了分析。紫外可见分光光度法显示，与对照样品相比，复合材料中生物活性物质的释放量高出约1.5至3倍。粒度分析表明分布范围较宽，为350至1300纳米。氮吸附-脱附（ASAP）证实了该材料的多孔性质，而扫描电子显微镜（SEM）和傅里叶变换红外光谱（FTIR）分析验证了所有组分的成功掺入。电动研究表明zeta电位值在+15毫伏至-32毫伏之间，表明胶体稳定性不同。所提出的复合材料作为药物和化妆品应用中生物活性物质的载体显示出有前景的潜力。
