Lin Sheng-Hsuan, Lin Ru-Jen, Chu Chia-Ling, Chen Yan-Lin, Fu Shih-Chen
Institute of Statistics, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.
Institute of Data Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.
Int J Mol Sci. 2025 Jun 26;26(13):6146. doi: 10.3390/ijms26136146.
Impulse control disorders (ICDs) are a debilitating non-motor symptom of Parkinson's disease (PD), often associated with dopaminergic therapy. However, their occurrence in some patients but not others suggests additional biological mechanisms, including the gut microbiome. In this study, we analyzed 191 PD patients (14 with ICDs, 177 without) using 16S rRNA gene sequencing to explore the association between gut microbiota and ICDs. No significant differences were observed in alpha or beta diversity between groups, but several bacterial taxa showed differential abundances. Notably, and were enriched in ICD patients. Functional pathway analysis revealed differences in metabolic pathways, including enrichment of and in the ICD group. These findings suggest that specific gut microbial taxa and their associated metabolic functions may contribute to ICDs in PD, highlighting a potential non-dopaminergic mechanism and opening new avenues for microbiome-targeted intervention.
冲动控制障碍（ICDs）是帕金森病（PD）一种使人衰弱的非运动症状，常与多巴胺能治疗相关。然而，它们在一些患者中出现而在另一些患者中未出现，这表明存在其他生物学机制，包括肠道微生物群。在本研究中，我们使用16S rRNA基因测序分析了191例PD患者（14例有ICDs，177例无ICDs），以探讨肠道微生物群与ICDs之间的关联。两组之间在α或β多样性方面未观察到显著差异，但几个细菌分类群显示出丰度差异。值得注意的是，[具体细菌分类群1]和[具体细菌分类群2]在ICD患者中富集。功能通路分析揭示了代谢通路的差异，包括[具体代谢通路1]和[具体代谢通路2]在ICD组中的富集。这些发现表明，特定的肠道微生物分类群及其相关的代谢功能可能导致PD患者出现ICDs，突出了一种潜在的非多巴胺能机制，并为以微生物群为靶点的干预开辟了新途径。
