Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Nat Commun. 2023 May 2;14(1):2501. doi: 10.1038/s41467-023-38248-4.
The microbiota-gut-brain axis has been suggested to play an important role in Parkinson's disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD. We show gut microbiota compositions are significantly altered in early PD and RBD compared with control and RBD-FDR. Depletion of butyrate-producing bacteria and enrichment of pro-inflammatory Collinsella have already emerged in RBD and RBD-FDR after controlling potential confounders including antidepressants, osmotic laxatives, and bowel movement frequency. Random forest modelling identifies 12 microbial markers that are effective to distinguish RBD from control. These findings suggest that PD-like gut dysbiosis occurs at the prodromal stages of PD when RBD develops and starts to emerge in the younger RBD-FDR subjects. The study will have etiological and diagnostic implications.
肠道微生物群-肠-脑轴被认为在帕金森病（PD）中发挥重要作用。在这里，我们进行了一项横断面研究，以描绘早期 PD、快速眼动睡眠行为障碍（RBD）、RBD 一级亲属（RBD-FDR）和健康对照者的肠道微生物群，这可以反映 PD 的肠-脑分期模型。我们发现，与对照组和 RBD-FDR 相比，早期 PD 和 RBD 患者的肠道微生物群组成明显改变。在控制了包括抗抑郁药、渗透压性泻药和排便频率在内的潜在混杂因素后，丁酸产生菌的减少和促炎柯林斯菌的富集已经出现在 RBD 和 RBD-FDR 中。随机森林模型确定了 12 种有效的微生物标志物，可将 RBD 与对照组区分开来。这些发现表明，当 RBD 发生并开始在年轻的 RBD-FDR 受试者中出现时，类似于 PD 的肠道菌群失调发生在 PD 的前驱期。这项研究将具有病因学和诊断学意义。
