Kępka-Borkowska Katarzyna, Chałaśkiewicz Katarzyna, Ogłuszka Magdalena, Borkowski Mateusz, Lepczyński Adam, Pareek Chandra Shekhar, Starzyński Rafał Radosław, Lichwiarska Elżbieta, Sultana Sharmin, Kalra Garima, Purohit Nihal, Gralak Barbara, Poławska Ewa, Pierzchała Mariusz
Department of Genomics and Biodiversity, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzębiec, Postępu St. 36A, 05-552 Magdalenka, Poland.
Department of Commercialization and Technology Transfer, Industrial Chemistry Institute, Łukasiewicz Research Network, Warsaw, Rydygiera St. 8, 01-793 Warsaw, Poland.
Int J Mol Sci. 2025 Jul 7;26(13):6534. doi: 10.3390/ijms26136534.
Aflatoxins, toxic secondary metabolites produced primarily by and , pose a significant global health concern due to their frequent presence in crops, food, and feed-especially under climate change conditions. This review addresses the growing threat of aflatoxins by analyzing recent advances in detection and mitigation. A comprehensive literature review was conducted, focusing on bioremediation, physical and chemical detoxification, and fungal growth inhibition strategies. The occurrence of aflatoxins in water systems was also examined, along with current detection techniques, removal processes, and regulatory frameworks. Emerging technologies such as molecular diagnostics, immunoassays, biosensors, and chromatographic methods are discussed for their potential to improve monitoring and control. Key findings highlight the increasing efficacy of integrative approaches combining biological and technological solutions and the potential of AI-based tools and portable devices for on-site detection. Intelligent packaging and transgenic crops are also explored for their role in minimizing contamination at the source. Overall, this review emphasizes the importance of continued interdisciplinary research and the development of sustainable, adaptive strategies to mitigate aflatoxin risks, thereby supporting food safety and public health in the face of environmental challenges.
黄曲霉毒素是主要由黄曲霉和寄生曲霉产生的有毒次生代谢产物,由于它们频繁出现在农作物、食品和饲料中,尤其是在气候变化条件下,因此对全球健康构成了重大威胁。本综述通过分析检测和缓解方面的最新进展,探讨了黄曲霉毒素日益增长的威胁。进行了全面的文献综述,重点关注生物修复、物理和化学解毒以及真菌生长抑制策略。还研究了水系统中黄曲霉毒素的存在情况,以及当前的检测技术、去除工艺和监管框架。讨论了分子诊断、免疫测定、生物传感器和色谱方法等新兴技术在改善监测和控制方面的潜力。主要研究结果突出了结合生物和技术解决方案的综合方法的日益提高的有效性,以及基于人工智能的工具和便携式设备用于现场检测的潜力。还探讨了智能包装和转基因作物在从源头上减少污染方面的作用。总体而言,本综述强调了持续开展跨学科研究以及制定可持续、适应性策略以减轻黄曲霉毒素风险的重要性,从而在面对环境挑战时保障食品安全和公众健康。