对盐的高血压作用敏感和有抗性的品系大鼠中19-去甲-脱氧皮质酮的排泄情况

19-nor-deoxycorticosterone excretion in rats bred for susceptibility and resistance to the hypertensive effects of salt.

作者信息

Dale S L, Holbrook M M, Melby J C

出版信息

Endocrinology. 1985 Dec;117(6):2424-7. doi: 10.1210/endo-117-6-2424.

Abstract

Rats susceptible (S/JR) and resistance (R/JR) to the hypertensive effect of salt were weaned at 28 days of age and placed on a high salt intake. Blood pressure, measured at 4-5 and 8-9 weeks of age (after 5 weeks of high salt intake), demonstrated a slight increase in R/JR rats and a highly significant increase in S/JR rats. Urinary fee 19-nor-deoxycorticosterone (19-nor-DOC) levels measured in weekly urine collections were found to be markedly elevated in S/JR rats compared to levels in R/JR rats. Since 19-nor-DOC has been shown to be a potent mineralocorticoid, the results suggest that elevated production of 19-nor-DOC may have a role in hypertension in rats susceptible to the hypertensive effects of salt.

摘要

对盐的高血压效应敏感（S/JR）和具有抗性（R/JR）的大鼠在28日龄断奶，并给予高盐饮食。在4 - 5周龄和8 - 9周龄（高盐饮食5周后）测量血压，结果显示R/JR大鼠血压略有升高，而S/JR大鼠血压则显著升高。每周收集尿液检测发现，与R/JR大鼠相比，S/JR大鼠尿中19 - 去甲 - 脱氧皮质酮（19 - nor - DOC）水平显著升高。由于19 - nor - DOC已被证明是一种强效盐皮质激素，这些结果表明，19 - nor - DOC产量升高可能在对盐的高血压效应敏感的大鼠高血压中起作用。