Valeriani Lavinia, Carrano Barbara, Vecchio Fabrizio
Fondazione Antea, Rome, Italy.
Department of Theoretical and Applied Sciences, eCampus University, Novedrate, Como, Italy.
Geroscience. 2025 Jul 12. doi: 10.1007/s11357-025-01781-9.
Assessing quality of life (QOL) in end-of-life patients is vital for understanding the complex impacts of terminal illnesses on individual well-being. This study aims to compare two widely used QOL assessment tools: the Karnofsky Performance Status Scale (KPSS) and the Short-Form-36 (SF-36) Health Survey among patients with late-stage diseases. KPSS, a clinician-rated scale measuring functional capacity, provides an objective perspective on a patient's clinical status. Conversely, the SF-36 offers a patient-reported overview across eight dimensions, including physical and mental health. The study enrolled 68 patients with an average Karnofsky score of about 37. Results demonstrate a significant interaction between Karnofsky scores and SF-36 dimensions, indicating that patients with higher Karnofsky scores reported better physical, social, and emotional functioning. Strong positive correlations were found between high Karnofsky scores and specific SF-36 components, including Physical Functioning, Role Physical, and Social Functioning, suggesting that these aspects critically influence overall QOL. Notably, no correlation was identified between age and KPSS, highlighting that disease severity rather than age impacts QOL. Findings underscore the complementary roles of KPSS and SF-36 in assessing QOL in terminally ill patients; while some measures in SF-36 aligned closely with KPSS, others offered essential insights into patient experiences. This comprehensive approach emphasizes the need for robust QOL evaluations in palliative care, facilitating more patient-centered care aligned with individuals' values and needs.
评估临终患者的生活质量(QOL)对于理解晚期疾病对个体幸福感的复杂影响至关重要。本研究旨在比较两种广泛使用的生活质量评估工具:卡诺夫斯基功能状态量表(KPSS)和简短健康调查问卷36项版本(SF - 36),用于晚期疾病患者。KPSS是一种由临床医生评定的测量功能能力的量表,能对患者的临床状况提供客观视角。相反,SF - 36提供了患者报告的涵盖八个维度的概况,包括身心健康。该研究招募了68名平均卡诺夫斯基评分约为37分的患者。结果表明卡诺夫斯基评分与SF - 36维度之间存在显著交互作用,这表明卡诺夫斯基评分较高的患者在身体、社交和情感功能方面表现更好。在高卡诺夫斯基评分与特定的SF - 36组成部分之间发现了强正相关,包括身体功能、身体角色和社会功能,这表明这些方面对总体生活质量有至关重要的影响。值得注意的是,年龄与KPSS之间未发现相关性,这突出表明疾病严重程度而非年龄影响生活质量。研究结果强调了KPSS和SF - 36在评估临终患者生活质量方面的互补作用;虽然SF - 36中的一些测量指标与KPSS密切相关,但其他指标提供了关于患者体验的重要见解。这种综合方法强调了在姑息治疗中进行强有力的生活质量评估的必要性,促进更以患者为中心的护理,使其符合个人的价值观和需求。