Jackson P C, Jones M, Brimble C E, Hart J
Eur J Nucl Med. 1985;11(5):186-9. doi: 10.1007/BF00251372.
The use of region-of-interest (ROI) techniques to quantify data obtained in radionuclide images is commonplace. However, the reproducibility of quantitation due to inter- and intra-observer variations using particular methods of deriving ROIs is often not appreciated. We examined such variations in the results obtained by four independent observers of varying experience using four methods of depicting a ROI about an organ. The set of image data consisted of renal scans with varying target-to-background ratios, and the ROI facilities included two edge-detection methods. The results indicated that, once observers were experienced with edge-detection methods, a lower inter- and intra-observer variation could be achieved, although the technique of 'shrinking' a ROI about a subjectively chosen display level was reasonably satisfactory. In terms or reproducibility, the least satisfactory method of depicting a ROI was the commonly used manually guided 'bug' around arbitrarily chosen display levels representing the boundary of an organ.
使用感兴趣区域（ROI）技术对放射性核素图像中获取的数据进行量化是很常见的。然而，使用特定的ROI推导方法时，由于观察者间和观察者内的差异导致的定量重复性往往未得到重视。我们使用四种描绘器官ROI的方法，研究了四位经验不同的独立观察者所获得结果中的此类差异。图像数据集包括具有不同靶本底比的肾脏扫描，ROI工具包括两种边缘检测方法。结果表明，一旦观察者熟悉了边缘检测方法，就可以实现较低的观察者间和观察者内差异，尽管围绕主观选择的显示水平“收缩”ROI的技术也相当令人满意。就可重复性而言，描绘ROI最不令人满意的方法是常用的围绕代表器官边界的任意选择的显示水平手动引导“标记”。
