Catanese B, Valeri P, Durando L, Gismondi A
Pharmacol Res Commun. 1985 May;17(5):425-32. doi: 10.1016/0031-6989(85)90077-3.
The distribution of bendazac in the plasma and some rat tissues was studied after single oral administration of 14C bendazac L-lysine salt. The drug is distributed in varying amounts in the liver, kidneys, spleen, muscle, plasma and lens. In these tissues, the drug kinetics is similar, except for the lens where elimination of the drug is slower. More than 80% of the radioactivity administered is excreted through the urine and feces. Fecal excretion is due to the high biliary excretion.
单次口服14C苄达酸L-赖氨酸盐后，研究了苄达酸在大鼠血浆和一些组织中的分布情况。药物在肝脏、肾脏、脾脏、肌肉、血浆和晶状体中的分布量各不相同。在这些组织中，药物动力学相似，但晶状体中药物消除较慢。给药的放射性物质80%以上通过尿液和粪便排出。粪便排泄是由于胆汁排泄量高。
