Barzilay J, Schechter J, Froom P, Rakowsky E, Rahima M, Mor C
Eur J Surg Oncol. 1985 Dec;11(4):337-41.
Thirteen cases of malignant lymphoma, exclusive of mycosis fungoides, with initial involvement of the skin, were selected from 391 consecutive patients with non-Hodgkin's lymphoma. Their clinical course was correlated to histological subtype. All patients (5/5) with 'favourable' histology had single indurated plaques without extracutaneous involvement, and remained in complete remission for at least 5 years after local radiation therapy. In contrast, all those with 'unfavourable' histology not lost to follow-up (7/7) suffered relapse or died within a 2-year period. They generally had multiple skin lesions and extracutaneous involvement at diagnosis or shortly afterwards. We conclude that histological subtype is an important variable in predicting clinical course in those with cutaneous malignant lymphoma.
在391例非霍奇金淋巴瘤患者中，选取了13例初始累及皮肤的恶性淋巴瘤病例（蕈样肉芽肿除外）。将其临床病程与组织学亚型进行关联分析。所有组织学表现为“预后良好”的患者（5/5）均有单个硬结性斑块，无皮肤外受累，局部放疗后至少5年保持完全缓解。相比之下，所有组织学表现为“预后不良”且未失访的患者（7/7）在2年内均复发或死亡。他们在诊断时或之后不久通常有多处皮肤病变和皮肤外受累。我们得出结论，组织学亚型是预测皮肤恶性淋巴瘤患者临床病程的一个重要变量。
