Zhang Fengxian, Cheng Lin, Qin Sifan, Wang Liwei, Liu Yun, Liu Yuxiu, Yang Jinhong, Fang Shirong, An Na, Zhang Yufeng, Liu Jiang
Shandong Second Medical University, Weifang, Shandong, China.
Central Hospital of Zibo, Zibo, Shandong, China.
Support Care Cancer. 2025 Jul 14;33(8):689. doi: 10.1007/s00520-025-09741-x.
To assess the effects of aromatherapy massage on sleep quality and mental and psychological disorders in breast cancer survivors (BCS) undergoing chemotherapy.
The study was a prospective, double-blind, randomized, placebo-controlled trial. Eligible breast cancer patients were enrolled in this study. Participants were randomly assigned to either the intervention group (received lavender aromatherapy) or the placebo group (received sweet almond oil massage). Aromatherapists focused their massage on specific areas of the body (from the lumbosacral area to the soles of the feet, and then from the shoulders to the palms of the hands). From baseline to four weeks after the intervention, the Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality, the Visual Analog Scale (VAS) was used to assess pain response, the Mini-Mental State Examination (MMSE) score was used to assess cognitive function, the Beck Anxiety Inventory (BAI) was used to assess anxiety, and the Beck Depression Inventory Second Version (BDI-II) was used to assess depression in patients. All statistical analyses were conducted using STATA software (version 16.0), with a P-value < 0.05 considered statistically significant.
Ultimately, a total of 96 participants were divided into the intervention group (n = 47) and the placebo group (n = 51). The baseline characteristics were statistically comparable between the two groups. Statistically significant differences were observed in sleep quality scores (7.51 ± 2.90 vs 9.71 ± 2.67, P < 0.001), anxiety scores (20.26 ± 6.73 vs 24.10 ± 6.46, P = 0.005), and pain response (6.66 ± 1.45 vs 7.41 ± 1.19, P = 0.006) of the intervention group compared to the control group at the 4th week post-intervention. However, there was no significant difference in depression scores (29.43 ± 7.17 vs 30.88 ± 6.26, P = 0.286) and cognitive function scores (28.06 ± 1.55 vs 27.51 ± 1.97, P = 0.128) between the two groups.
Aroma massage with lavender essential oil may have a positive effect for BCS undergoing chemotherapy and warrants further promotion.
This trial was registered at www.
gov (Registration Number: NCT06338527, Registration Date: March 28, 2024).
评估芳香疗法按摩对接受化疗的乳腺癌幸存者（BCS）睡眠质量及精神心理障碍的影响。
本研究为前瞻性、双盲、随机、安慰剂对照试验。符合条件的乳腺癌患者纳入本研究。参与者被随机分为干预组（接受薰衣草芳香疗法）或安慰剂组（接受甜杏仁油按摩）。芳香疗法按摩师将按摩重点放在身体特定部位（从腰骶部到脚底，然后从肩部到手掌）。从基线到干预后四周，使用匹兹堡睡眠质量指数（PSQI）评估睡眠质量，视觉模拟量表（VAS）评估疼痛反应，简易精神状态检查表（MMSE）评分评估认知功能，贝克焦虑量表（BAI）评估焦虑，贝克抑郁量表第二版（BDI-II）评估患者抑郁情况。所有统计分析均使用STATA软件（版本16.0）进行，P值<0.05被认为具有统计学意义。
最终，共96名参与者被分为干预组（n = 47）和安慰剂组（n = 51）。两组的基线特征在统计学上具有可比性。干预后第4周，干预组与对照组相比，睡眠质量得分（7.51±2.90 vs 9.71±2.67，P<0.001）、焦虑得分（20.26±6.73 vs 24.10±6.46，P = 0.005）和疼痛反应（6.66±1.45 vs 7.41±1.19，P = 0.006）存在统计学显著差异。然而，两组在抑郁得分（29.43±7.17 vs 30.88±6.26，P = 0.286）和认知功能得分（28.06±1.55 vs 27.51±1.97，P = 0.128）方面无显著差异。
薰衣草精油芳香按摩可能对接受化疗的BCS有积极作用，值得进一步推广。
本试验在www.CLINICALTRIALS.gov上注册（注册号：NCT06338527，注册日期：2024年3月28日）。
