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Glycolysis hijacked: a novel pathogenic role of lipoprotein(a) in valve disease.

作者信息

Weiss Luisa, Aikawa Elena

机构信息

Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 3 Blackfan Street, Boston, MA 02115, USA.

Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

出版信息

Eur Heart J Open. 2025 Jun 6;5(4):oeaf069. doi: 10.1093/ehjopen/oeaf069. eCollection 2025 Jul.

DOI:10.1093/ehjopen/oeaf069
PMID:40654528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12246370/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa68/12246370/375680851873/oeaf069f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa68/12246370/375680851873/oeaf069f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa68/12246370/375680851873/oeaf069f1.jpg

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本文引用的文献

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Free Radic Biol Med. 2024 Jan;210:130-145. doi: 10.1016/j.freeradbiomed.2023.11.010. Epub 2023 Nov 18.
2
Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease.主要促成因子超家族结构域包含物 5 的抑制作用可减少心脏瓣膜病中脂蛋白(a)的摄取和钙化。
Circulation. 2024 Jan 30;149(5):391-401. doi: 10.1161/CIRCULATIONAHA.123.066822. Epub 2023 Nov 8.
3
Lipoprotein(a) and calcific aortic valve disease: current evidence and future directions.
脂蛋白(a)与钙化性主动脉瓣疾病：当前的证据与未来方向。
Curr Opin Clin Nutr Metab Care. 2024 Jan 1;27(1):77-86. doi: 10.1097/MCO.0000000000000976. Epub 2023 Aug 28.
4
Plasminogen Receptors Promote Lipoprotein(a) Uptake by Enhancing Surface Binding and Facilitating Macropinocytosis.纤溶酶原受体通过增强表面结合和促进巨胞饮作用促进脂蛋白(a)摄取。
Arterioscler Thromb Vasc Biol. 2023 Oct;43(10):1851-1866. doi: 10.1161/ATVBAHA.123.319344. Epub 2023 Aug 17.
5
Inclisiran, Low-Density Lipoprotein Cholesterol and Lipoprotein (a).英克西兰、低密度脂蛋白胆固醇和脂蛋白(a)
Pharmaceuticals (Basel). 2023 Apr 12;16(4):577. doi: 10.3390/ph16040577.
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Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response.抑制 PFKFB3 驱动的糖酵解可抑制血管内皮细胞向间充质细胞转化和纤维化反应。
Signal Transduct Target Ther. 2022 Sep 1;7(1):303. doi: 10.1038/s41392-022-01097-6.
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PALMD regulates aortic valve calcification via altered glycolysis and NF-κB-mediated inflammation.PALMD通过改变糖酵解和NF-κB介导的炎症反应来调节主动脉瓣钙化。
J Biol Chem. 2022 May;298(5):101887. doi: 10.1016/j.jbc.2022.101887. Epub 2022 Apr 1.
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Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis.脂蛋白(a)通过单细胞外囊泡分析揭示可诱导血管钙化
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J Am Coll Cardiol. 2019 May 7;73(17):2150-2162. doi: 10.1016/j.jacc.2019.01.070.