Abedini Robabeh, Rezayat Azadeh, Ghandi Narges, Varghaei Aida, Sedaghat Mojtaba, Mahmoudi Hamidreza
Department of Dermatology, Tehran University of Medical Sciences, Razi Hospital, Tehran, Iran.
Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Int J Trichology. 2025 Jan-Feb;17(1):25-31. doi: 10.4103/ijt.ijt_37_22. Epub 2025 Jun 23.
Diphenylcyclopropenone (DPCP) is an effective treatment in severe alopecia areata (AA). Platelet-rich plasma (PRP) has been introduced as an effective modality in AA. We present the first study to evaluate and compare the efficacy and tolerability of DPCP alone and DPCP in combination with PRP in the treatment of severe AA.
This is a comparative, randomized, double-blind study that included 14 patients with severe AA. Participants received weekly DPCP plus monthly PRP to treat alopecia patches on one side of their scalp (group 1) and DPCP plus placebo on the other side (group 2). Patient's response was evaluated with the severity of alopecia tool (SALT) score and trichoscopy scores. PRP was injected for 3 times and patients were followed for 6 months.
Among enrolled patients, 7 (50%) experienced a hair regrowth >50%. The mean SALT score and trichoscopy scaled scores decreased over time for both the groups. Nevertheless, there were no significant differences between groups. The side effect was not noticeable in either group.
This is the first study to investigate a synergistic effect with DPCP and PRP. According to this study, PRP is ineffective as an adjunct to DPCP for augmenting its effectiveness.
二苯环丙烯酮（DPCP）是重度斑秃（AA）的一种有效治疗方法。富血小板血浆（PRP）已被引入作为AA的一种有效治疗方式。我们开展了第一项研究，以评估和比较单独使用DPCP以及DPCP联合PRP治疗重度AA的疗效和耐受性。
这是一项比较性、随机、双盲研究，纳入了14例重度AA患者。参与者每周接受DPCP治疗，每月接受PRP治疗，用于治疗头皮一侧的脱发斑（第1组），另一侧接受DPCP加安慰剂治疗（第2组）。使用脱发严重程度工具（SALT）评分和毛囊镜检查评分评估患者的反应。PRP注射3次，对患者随访6个月。
在纳入的患者中，7例（50%）的头发生长超过50%。两组的平均SALT评分和毛囊镜检查量表评分均随时间下降。然而，两组之间没有显著差异。两组均未观察到明显的副作用。
这是第一项研究DPCP和PRP协同作用的研究。根据本研究，PRP作为DPCP的辅助治疗以增强其疗效是无效的。
