Balakrishnan Anumod, Joy Bifi, Thyvalappil Anoop, Mathew Pretty, Sreenivasan Ajayakumar, Sridharan Rajiv
Department of Dermatology, Govt. Medical College, Kannur, Kerala, India.
Indian Dermatol Online J. 2020 Sep 19;11(6):920-924. doi: 10.4103/idoj.IDOJ_6_20. eCollection 2020 Nov-Dec.
Alopecia areata (AA) is a chronic nonscarring alopecia that involves hair follicles and is characterized by patchy areas of hair loss without any signs of clinical inflammation. Platelet-ri-ch plasma (PRP) has a high platelet concentration. Anti-inflammatory effect of PRP may be of great help in AA.
Study was conducted to compare the outcome of treatment and side effects of intralesional PRP versus triamcinolone in AA.
40 patients with alopecia areata were allocated into 2 groups and treated with triamcinolone and PRP injections. The response was analyzed by SALT score (severity of alopecia tool score) and hair regrowth grade (HRG) scale. Inferential statistical tools such as -test, Mann-Whitney U test, and Chi-square test were used.
16 patients in each group completed the study. While comparing the decrease in SALT score at different intervals of time, there was a significant difference in SALT score reduction during the second review between PRP group and triamcinolone group ( = 0.028). After the first and final review, results did not show any statistically significant difference between the two groups. While comparing the hair regrowth scale between treatments, there was no statistical significance. 12.5% patients in PRP group reported excellent response after final review (HRG scale 4), compared to none in triamcinolone group.
Platelet-rich plasma is a safe, effective, steroid sparing, and suitable alternative in AA. Only side effect noted was pain during injections in both the groups.
斑秃（AA）是一种慢性非瘢痕性脱发，累及毛囊，其特征为局部脱发区域，无任何临床炎症迹象。富血小板血浆（PRP）具有高血小板浓度。PRP的抗炎作用可能对斑秃有很大帮助。
进行研究以比较病灶内注射PRP与曲安奈德治疗斑秃的疗效及副作用。
将40例斑秃患者分为两组，分别接受曲安奈德和PRP注射治疗。通过SALT评分（脱发严重程度工具评分）和毛发再生分级（HRG）量表分析疗效。使用t检验、曼-惠特尼U检验和卡方检验等推断性统计工具。
每组各有16例患者完成研究。在比较不同时间间隔的SALT评分下降情况时，PRP组和曲安奈德组在第二次复查时SALT评分降低存在显著差异（P = 0.028）。第一次和最后一次复查后，两组结果未显示出任何统计学显著差异。在比较治疗间的毛发再生量表时，无统计学意义。PRP组12.5%的患者在最后复查后报告有极佳反应（HRG量表4级），而曲安奈德组无此情况。
富血小板血浆在斑秃治疗中是一种安全、有效、可节省类固醇且合适的替代方法。两组仅观察到的副作用是注射时疼痛。
