Department of Dermatology, University of California Irvine, Irvine, California, USA.
Department of Dermatology, University of California Irvine, Irvine, California, USA.
J Investig Dermatol Symp Proc. 2020 Nov;20(1):S50-S54. doi: 10.1016/j.jisp.2020.05.008.
Alopecia areata (AA) is an autoimmune hair loss condition that is difficult to treat and frequently disruptive to the psychosocial well-being of patients. Platelet-rich plasma (PRP) is an innovative therapy that provides concentrated GFs that impart anti-inflammatory effects. Optical coherence tomography (OCT) is a noninvasive imaging modality with the potential for providing quantitative monitoring of AA response to PRP. Our objective is to share our experience using OCT to monitor the therapeutic progress of patients with AA treated with PRP. Two patients with patchy AA and one with alopecia universalis were treated with PRP three times at 6-week intervals as part of a larger clinical trial. Patients were followed from baseline to week 24 with OCT imaging. OCT demonstrates an increase in hair density associated with improvement in inflammation at week 24. Conversely, the patient with alopecia universalis did not experience any significant change in follicular activity. This case series exemplifies the potential of PRP in inflammatory regulation as well as hair regrowth in patchy AA, whereas there is no notable advantage in alopecia universalis. Our findings add evidence on the possible value of OCT in quantitatively assessing hair growth progress throughout a treatment course.
斑秃（AA）是一种自身免疫性脱发疾病，难以治疗，常对患者的社会心理健康造成干扰。富血小板血浆（PRP）是一种创新疗法，可提供浓缩的生长因子，发挥抗炎作用。光学相干断层扫描（OCT）是一种非侵入性成像方式，具有对 PRP 治疗 AA 反应进行定量监测的潜力。我们的目的是分享使用 OCT 监测接受 PRP 治疗的 AA 患者治疗进展的经验。两名斑片状 AA 患者和一名全秃患者作为更大规模临床试验的一部分，每 6 周接受 3 次 PRP 治疗。患者从基线到第 24 周接受 OCT 成像随访。OCT 显示，与第 24 周的炎症改善相关，毛发密度增加。相反，全秃患者的毛囊活动没有明显变化。该病例系列举例说明了 PRP 在炎症调节以及斑片状 AA 中的毛发生长中的潜在作用，而在全秃中则没有明显优势。我们的研究结果进一步证明了 OCT 在评估整个治疗过程中毛发生长进展方面的可能价值。
