Godfrey Kate, Weiss Brandon, Zhang Xinhu, Spriggs Meg, Peill Joseph, Lyons Taylor, Carhart-Harris Robin, Erritzoe David
Centre for Psychedelic Research, Division of Psychiatry, Department of Brain Sciences, Imperial College London, UK.
Center for Psychedelic and Consciousness Research, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, MD, USA.
Neurosci Appl. 2024 Dec 2;4:104092. doi: 10.1016/j.nsa.2024.104092. eCollection 2025.
This study investigated the effects of a single high-dose of psilocybin on personality traits in psychedelic-naïve healthy volunteers. These data originate from a larger within-subjects fixed-order design trial, where a single high dose of psilocybin (25 mg) was administered in a psychologically supportive setting and was compared against a (one-month) prior, 1 mg 'placebo' dose. Personality shifts were assessed by the Big Five Inventory and the Big Five Aspect Scale, while the Altered States of Consciousness questionnaire (5D-ASC) and the Psychological Insight Scale gauged the acute psychological effects of the substance. Electroencephalography provided neurophysiological insights, specifically examining alpha power and Lempel-Ziv complexity (LZc). Results indicated significant reductions in neuroticism one month after 25 mg psilocybin administration, a finding consistent with prior studies. Reductions in neuroticism were moderated by the subjective meaningfulness of the psychedelic experience, as well as by the dread of ego dissolution subscale of the 5D-ASC, suggesting a relationship between acute drug effects and enduring personality alterations. Thus, this study substantiates the role of acute psychedelic states in catalysing lasting personality transformations in a generally beneficial direction, with broader implications for therapeutic applications and understanding of personality dynamics.
本研究调查了单次高剂量裸盖菇素对初次接触迷幻剂的健康志愿者人格特质的影响。这些数据源自一项更大规模的受试者内固定顺序设计试验，在该试验中，单次高剂量的裸盖菇素（25毫克）在心理支持环境下给药，并与之前（一个月前）的1毫克“安慰剂”剂量进行比较。人格变化通过大五人格量表和大五人格方面量表进行评估，而意识状态改变问卷（5D-ASC）和心理洞察力量表则衡量了该物质的急性心理效应。脑电图提供了神经生理学见解，特别检查了阿尔法波功率和莱姆佩尔-齐夫复杂度（LZc）。结果表明，服用25毫克裸盖菇素一个月后，神经质显著降低，这一发现与先前的研究一致。神经质的降低受到迷幻体验的主观意义以及5D-ASC中自我解体恐惧子量表的调节，表明急性药物效应与持久的人格改变之间存在关联。因此，本研究证实了急性迷幻状态在催化持久的人格转变方面所起的作用，这种转变总体上朝着有益的方向发展，对治疗应用和人格动力学的理解具有更广泛的意义。
